Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Study or subgroup AS+MQ AL6 Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Lefevre 1999 THA 0/53 7/155 20.0 % 0.19 [ 0.01, 3.32 ]<br />
Hutagalung 2002 THA 14/233 13/232 67.7 % 1.07 [ 0.52, 2.23 ]<br />
Subtotal (95% CI) 333 521 100.0 % 0.80 [ 0.41, 1.58 ]<br />
Total events: 14 (AS+MQ), 24 (AL6)<br />
Heterogeneity: Chi 2 = 1.97, df = 2 (P = 0.37); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 0.64 (P = 0.52)<br />
0.005 0.1 1 10 200<br />
Favours ASMQ Favours AL<br />
Analysis 6.4. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 4 Total<br />
Failure (P. falciparum) Day 28 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 6 Artesunate plus mefloquine vs Artemether-lumefantrine<br />
Outcome: 4 Total Failure (P. falciparum) Day 28 PCR adjusted<br />
Study or subgroup AS+MQ AL6 Risk Ratio Risk Ratio<br />
1 Africa<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/142 0/147 0.0 [ 0.0, 0.0 ]<br />
Sagara 2005b MLI 9/192 7/162 1.08 [ 0.41, 2.85 ]<br />
Subtotal (95% CI) 334 309 1.08 [ 0.41, 2.85 ]<br />
Total events: 9 (AS+MQ), 7 (AL6)<br />
Heterogeneity: Chi 2 = 0.0, df = 0 (P = 1.00); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 0.17 (P = 0.87)<br />
2 Asia<br />
Van Vugt 1998 THA 0/47 3/133 0.40 [ 0.02, 7.58 ]<br />
Lefevre 1999 THA 0/53 6/154 0.22 [ 0.01, 3.85 ]<br />
Hutagalung 2002 THA 9/228 2/221 4.36 [ 0.95, 19.96 ]<br />
Subtotal (95% CI) 328 508 1.43 [ 0.53, 3.86 ]<br />
Total events: 9 (AS+MQ), 11 (AL6)<br />
Heterogeneity: Chi 2 = 4.43, df = 2 (P = 0.11); I 2 =55%<br />
Test <strong>for</strong> overall effect: Z = 0.70 (P = 0.48)<br />
Total (95% CI) 662 817 1.25 [ 0.63, 2.50 ]<br />
Total events: 18 (AS+MQ), 18 (AL6)<br />
Heterogeneity: Chi 2 = 4.67, df = 3 (P = 0.20); I 2 =36%<br />
Test <strong>for</strong> overall effect: Z = 0.64 (P = 0.52)<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.005 0.1 1 10 200<br />
Favours ASMQ Favours AL<br />
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