Artemisinin-based combination therapy for ... - The Cochrane Library

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Figure 5. How does Artesunate plus mefloquine perform? Summary of primary outcome: Effectiveness: Total Failure (P. falciparum) PCR adjusted. Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 22
Figure 6. Olliaro-Vaillant plot. Day 28 PCR adjusted treatment failure data for trials of AS+MQ against all comparators are presented in this plot.The horizontal red line represents the WHO standard of 10% treatment failure (PCR corrected). Plots below this line represent trials where AS+MQ performed to this standard.The vertical blue line represents no difference between the two drugs. Plots to the right of this line represent trials where AS+MQ performed better than the comparator drug, and plots to the left represent trials where the comparator drug performed better than AS+MQ. • AL6 and AS+AQ performed well in almost all studies they were involved in but Kamya 2006 UGA found failure rates in excess of 10% with AL6 and Yeka 2004 UGA reported > 10% failure with AS+AQ (Figure 7; Figure 8; Figure 9; Figure 10). Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 23
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Tran 2002 VNM Methods Trial design:
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Van Vugt 1998 THA Methods Trial des
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Yeka 2007 UGA (Continued) Free of o
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Zongo 2007 BFA (Continued) Novartis
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(Continued) Fofana 2005 Conference
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D A T A A N D A N A L Y S E S Compa
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2.2 Asia 1 317 Risk Ratio (M-H, Fix
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Comparison 5. Dihydroartemisinin-pi
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Comparison 8. Artesunate plus meflo
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Comparison 10. Artemether-lumefantr
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Comparison 12. Artesunate plus amod
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5.2 DHA-P 3 doses 3 1116 Risk Ratio
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Comparison 21. How does Artesunate
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Analysis 1.3. Comparison 1 Dihydroa
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Analysis 6.6. Comparison 6 Artesuna
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Analysis 9.2. Comparison 9 Artemeth
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Analysis 20.1. Comparison 20 How do
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Analysis 21.1. Comparison 21 How do
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(Continued) 2. How does artesunate
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(Continued) Sensitivity analysis 1
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(Continued) Smithuis 2004 MMR (652
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Dihydroartemisinin-piperaquine vs A
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Artesunate plus mefloquine vs Amodi
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Artemether-lumefantrine vs Artesuna
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PCR = polymerase chain reaction PCV
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Footnotes 1 Data were also availabl
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(Continued) justed Vivax efficacy:
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1 Dorsey 2006 UGA; Faye 2003 SEN; K
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