Artemisinin-based combination therapy for ... - The Cochrane Library

More documents

Recommendations

Info

$Interventions for treating proximal humeral fractures in adults (Review)$

Analysis 9.9. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 9 Sensitivity analysis: Total Failure Day 28 PCR unadjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 9 Artemether-lumefantrine vs Artesunate plus amodiaquine Outcome: 9 Sensitivity analysis: Total Failure Day 28 PCR unadjusted Study or subgroup AL6 AS+AQ Risk Ratio Weight Risk Ratio 1 Total Failure (P. falciparum) Day 28 PCR unadjusted n/N n/N M-H,Random,95% CI M-H,Random,95% CI Faye 2003 SEN 0/147 9/349 1.2 % 0.12 [ 0.01, 2.12 ] Mutabingwa 2004 TZA 103/485 193/472 23.5 % 0.52 [ 0.42, 0.64 ] Guthmann 2004 AGO 2/61 4/64 3.3 % 0.52 [ 0.10, 2.76 ] Bukirwa 2005 UGA 102/202 133/201 24.2 % 0.76 [ 0.64, 0.90 ] Falade 2005 NGA 3/62 5/61 4.5 % 0.59 [ 0.15, 2.36 ] Owusu-Agyei 2006 GHA 42/152 22/151 16.9 % 1.90 [ 1.19, 3.02 ] Dorsey 2006 UGA 5/100 7/105 6.4 % 0.75 [ 0.25, 2.29 ] Adjei 2006 GHA 6/103 5/107 6.0 % 1.25 [ 0.39, 3.96 ] Kobbe 2007 GHA 23/103 15/96 14.0 % 1.43 [ 0.79, 2.57 ] Subtotal (95% CI) 1415 1606 100.0 % 0.88 [ 0.60, 1.27 ] Total events: 286 (AL6), 393 (AS+AQ) Heterogeneity: Tau 2 = 0.16; Chi 2 = 34.92, df = 8 (P = 0.00003); I 2 =77% Test for overall effect: Z = 0.70 (P = 0.49) 2 Total Failure Day 28 PCR unadjusted (trials with baseline differences included) Faye 2003 SEN 0/147 9/349 0.9 % 0.12 [ 0.01, 2.12 ] Martensson 2003 TZA 14/197 57/206 10.6 % 0.26 [ 0.15, 0.45 ] Koram 2003 GHA 8/47 13/51 7.4 % 0.67 [ 0.30, 1.47 ] Van den Broek 2004 ZAR 13/100 31/97 10.1 % 0.41 [ 0.23, 0.73 ] Mutabingwa 2004 TZA 103/485 193/472 16.9 % 0.52 [ 0.42, 0.64 ] Guthmann 2004 AGO 2/61 4/64 2.4 % 0.52 [ 0.10, 2.76 ] Falade 2005 NGA 3/62 5/61 3.2 % 0.59 [ 0.15, 2.36 ] Bukirwa 2005 UGA 102/202 133/201 17.4 % 0.76 [ 0.64, 0.90 ] Owusu-Agyei 2006 GHA 42/152 22/151 12.1 % 1.90 [ 1.19, 3.02 ] Adjei 2006 GHA 6/103 5/107 4.3 % 1.25 [ 0.39, 3.96 ] Dorsey 2006 UGA 5/100 7/105 4.6 % 0.75 [ 0.25, 2.29 ] Kobbe 2007 GHA 23/103 15/96 10.0 % 1.43 [ 0.79, 2.57 ] 0.002 0.1 1 10 500 Favours AL6 Favours AS+AQ Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. (Continued ...) 172
(... Continued) Study or subgroup AL6 AS+AQ Risk Ratio Weight Risk Ratio n/N n/N M-H,Random,95% CI M-H,Random,95% CI Subtotal (95% CI) 1759 1960 100.0 % 0.69 [ 0.49, 0.97 ] Total events: 321 (AL6), 494 (AS+AQ) Heterogeneity: Tau 2 = 0.20; Chi 2 = 51.61, df = 11 (P
Page 1 and 2:
Artemisinin-based combination thera
Page 3 and 4:
Analysis 2.2. Comparison 2 Dihydroa
Page 5 and 6:
Analysis 10.5. Comparison 10 Arteme
Page 7 and 8:
[Intervention Review] Artemisinin-b
Page 9 and 10:
B A C K G R O U N D Malaria is a di
Page 11 and 12:
drugs and the treatment comparisons
Page 13 and 14:
this analysis into participants who
Page 15 and 16:
Figure 1. Methodological quality su
Page 17 and 18:
confidence intervals of the estimat
Page 19 and 20:
Anaemia Hasugian 2005 IDN found tha
Page 21 and 22:
Three trials report significantly m
Page 23 and 24:
or those treated for P. vivax at ba
Page 25 and 26:
Early vomiting Not reported. D I S
Page 27 and 28:
Figure 4. Olliaro-Vaillant plot. Da
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Figure 10. Olliaro-Vaillant plot. D
Page 35 and 36:
of findings tables’. For these ta
Page 37 and 38:
Huambo and Bie provinces, central A
Page 39 and 40:
References to studies excluded from
Page 41 and 42:
Adjuik 2004 Adjuik M, Babiker A, Ga
Page 43 and 44:
C H A R A C T E R I S T I C S O F S
Page 45 and 46:
Ashley 2003a THA (Continued) Outcom
Page 47 and 48:
Ashley 2003b THA (Continued) Alloca
Page 49 and 50:
Ashley 2005 THA (Continued) Exclusi
Page 51 and 52:
Bonnet 2004 GIN (Continued) Item Au
Page 53 and 54:
Bukirwa 2005 UGA Methods Trial desi
Page 55 and 56:
Djimde 2004 MLI (Continued) • AS
Page 57 and 58:
Dorsey 2006 UGA (Continued) Item Au
Page 59 and 60:
Fanello 2004 RWA Methods Trial desi
Page 61 and 62:
Faye 2003 SEN (Continued) Outcomes
Page 63 and 64:
Grande 2005 PER (Continued) Allocat
Page 65 and 66:
Guthmann 2004 AGO (Continued) All d
Page 67 and 68:
Hasugian 2005 IDN Methods Trial des
Page 69 and 70:
Hutagalung 2002 THA (Continued) 5.
Page 71 and 72:
Janssens 2003 KHM (Continued) Free
Page 73 and 74:
Karema 2004 RWA (Continued) Interve
Page 75 and 76:
Karunajeewa 2007 PNG (Continued) Ri
Page 77 and 78:
Kobbe 2007 GHA (Continued) Exclusio
Page 79 and 80:
Koram 2003 GHA (Continued) Adequate
Page 81 and 82:
Martensson 2003 TZA Methods Trial d
Page 83 and 84:
Mayxay 2003 LAO (Continued) 1. Feve
Page 85 and 86:
Menard 2006 MDG Methods Trial desig
Page 87 and 88:
Mens 2007 KEN (Continued) Risk of b
Page 89 and 90:
Mutabingwa 2004 TZA (Continued) •
Page 91 and 92:
Owusu-Agyei 2006 GHA (Continued) Fr
Page 93 and 94:
Sagara 2005b MLI (Continued) • 25
Page 95 and 96:
Smithuis 2004 MMR (Continued) Risk
Page 97 and 98:
Stohrer 2003 LAO Methods Trial desi
Page 99 and 100:
Swarthout 2004 ZAR (Continued) Note
Page 101 and 102:
Tran 2002 VNM Methods Trial design:
Page 103 and 104:
Van den Broek 2003a BGD (Continued)
Page 105 and 106:
Van Vugt 1998 THA Methods Trial des
Page 107 and 108:
Yeka 2004 UGA (Continued) Risk of b
Page 109 and 110:
Yeka 2007 UGA (Continued) Free of o
Page 111 and 112:
Zongo 2007 BFA (Continued) Novartis
Page 113 and 114:
(Continued) Fofana 2005 Conference
Page 115 and 116:
D A T A A N D A N A L Y S E S Compa
Page 117 and 118:
2.2 Asia 1 317 Risk Ratio (M-H, Fix
Page 119 and 120:
Comparison 5. Dihydroartemisinin-pi
Page 121 and 122:
Comparison 8. Artesunate plus meflo
Page 123 and 124:
Comparison 10. Artemether-lumefantr
Page 125 and 126:
Comparison 12. Artesunate plus amod
Page 127 and 128: 5.2 DHA-P 3 doses 3 1116 Risk Ratio
Page 129 and 130: Comparison 21. How does Artesunate
Page 131 and 132: Analysis 1.3. Comparison 1 Dihydroa
Page 137 and 138: (... Continued) Study or subgroup D
Page 139 and 140: Analysis 1.12. Comparison 1 Dihydro
Page 163 and 164: (... Continued) Study or subgroup A
Page 165 and 166: Analysis 6.6. Comparison 6 Artesuna
Page 173 and 174: Analysis 9.2. Comparison 9 Artemeth
Page 177: Analysis 9.8. Comparison 9 Artemeth
Page 183 and 184: Analysis 10.2. Comparison 10 Arteme
Page 197 and 198: Analysis 12.2. Comparison 12 Artesu
Page 207 and 208: Analysis 14.2. Comparison 14 Dihydr
Page 219 and 220: Analysis 20.1. Comparison 20 How do
Page 221 and 222: Analysis 21.1. Comparison 21 How do
Page 223 and 224: (Continued) 2. How does artesunate
Page 225 and 226: (Continued) Sensitivity analysis 1
Page 227 and 228: (Continued) Smithuis 2004 MMR (652
Page 229 and 230:
Dihydroartemisinin-piperaquine vs A
Page 231 and 232:
(Continued) Mayxay 2003 LAO (220 pa
Page 233 and 234:
Artesunate plus mefloquine vs Amodi
Page 235 and 236:
(Continued) Faye 2003 SEN (509 part
Page 237 and 238:
Artemether-lumefantrine vs Artesuna
Page 239 and 240:
(Continued) Zongo 2005 BFA (521 par
Page 241 and 242:
(Continued) Faye 2003 SEN (521 part
Page 243 and 244:
PCR = polymerase chain reaction PCV
Page 245 and 246:
(Continued) Proportion with anaemia
Page 247 and 248:
(Continued) Vivax efficacy: P. viva
Page 249 and 250:
(Continued) Efficacy: Total Failure
Page 251 and 252:
(Continued) Outcomes Illustrative c
Page 253 and 254:
Page 255 and 256:
(Continued) GRADE Working Group gra
Page 257 and 258:
Footnotes 1 Data were also availabl
Page 259 and 260:
8 Very serious imprecision: There w
Page 261 and 262:
Page 263 and 264:
(Continued) justed Vivax efficacy:
Page 265 and 266:
(Continued) Harms: Serious adverse
Page 267 and 268:
(Continued) Harms: Early vomiting -
Page 269 and 270:
1 Dorsey 2006 UGA; Faye 2003 SEN; K
show all

Artemisinin-based combination therapy for ... - The Cochrane Library

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?