Artemisinin-based combination therapy for ... - The Cochrane Library

5.4 Mean haematocrit at
baseline
1 Mean Difference (IV, Fixed, 95% CI) Not estimable
5.5 Mean haematocrit at Day
28
1 Mean Difference (IV, Fixed, 95% CI) Not estimable
6 Proportion anaemic
(Haemoglobin < 11 g/dl)
1 Risk Ratio (M-H, Fixed, 95% CI) Totals not selected
6.1 At baseline 1 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
6.2 At day 28 1 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
7 Serious adverse events (including
deaths)
6 2749 Risk Ratio (M-H, Fixed, 95% CI) 1.11 [0.59, 2.08]
8 Early vomiting 5 1097 Risk Ratio (M-H, Fixed, 95% CI) 0.87 [0.59, 1.31]
9 Sensitivity analysis: Total Failure
Day 28 PCR unadjusted
12 Risk Ratio (M-H, Random, 95% CI) Subtotals only
9.1 Total Failure (P.
falciparum) Day 28 PCR
unadjusted
9 3021 Risk Ratio (M-H, Random, 95% CI) 0.88 [0.60, 1.27]
9.2 Total Failure Day 28 PCR
unadjusted (trials with baseline
differences included)
12 3719 Risk Ratio (M-H, Random, 95% CI) 0.69 [0.49, 0.97]
9.3 Total Failure Day 28 PCR
unadjusted (losses to follow up
included as failures)
9 3230 Risk Ratio (M-H, Random, 95% CI) 0.81 [0.62, 1.06]
9.4 Total Failure Day 28 PCR
unadjusted (losses to follow up
included as successes)
9 3230 Risk Ratio (M-H, Random, 95% CI) 0.89 [0.61, 1.30]
10 Sensitivity analysis: Total
Failure Day 28 PCR adjusted
11 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
10.1 Total Failure (P.
falciparum) Day 28 PCR
adjusted
8 1729 Risk Ratio (M-H, Fixed, 95% CI) 1.65 [0.95, 2.87]
10.2 Total Failure Day 28
PCR adjusted (trials with
baseline differences included)
11 2311 Risk Ratio (M-H, Fixed, 95% CI) 1.07 [0.69, 1.67]
10.3 Total Failure Day 28
PCR adjusted (indeterminate
PCR included as failures)
8 1747 Risk Ratio (M-H, Fixed, 95% CI) 1.72 [1.06, 2.78]
10.4 Total Failure Day 28
PCR adjusted (new infections
included as successes)
8 2064 Risk Ratio (M-H, Fixed, 95% CI) 1.70 [1.06, 2.75]
10.5 Total Failure Day 28
PCR adjusted (losses to follow
up included as failures)
8 2196 Risk Ratio (M-H, Fixed, 95% CI) 1.01 [0.78, 1.31]
10.6 Total Failure Day 28
PCR adjusted (losses to follow
up included as successes)
8 2196 Risk Ratio (M-H, Fixed, 95% CI) 1.75 [1.08, 2.83]
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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