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Nutrition Science and Everyday Application - beta v 0.1

Nutrition Science and Everyday Application - beta v 0.1

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CALCIUM: CRITICAL FOR BONES AND THROUGHOUT THE BODY 505<br />

Figure 9.4. The thyroid <strong>and</strong> parathyroid gl<strong>and</strong>s are located at the back of the neck.<br />

Let’s take a closer look at how the body regulates blood calcium levels. If the blood calcium<br />

concentration drops too low, the parathyroid gl<strong>and</strong>s release parathyroid hormone, or PTH.<br />

PTH then acts in several ways to increase blood calcium levels:<br />

1. PTH stimulates the activity of osteoclasts to release calcium from bone.<br />

2. PTH acts on the kidney to reduce the amount of calcium lost in the urine, returning<br />

more to circulation.<br />

3. PTH stimulates enzymes in the kidney that convert vitamin D to its active form, also<br />

called calcitriol. Activated vitamin D acts on the intestine to increase the absorption<br />

of calcium. Vitamin D also works together with PTH to stimulate release of calcium<br />

from the bone <strong>and</strong> reduce calcium loss in urine.<br />

Once blood calcium levels are normal, PTH levels drop, turning off all of these mechanisms<br />

of increasing calcium.<br />

On the other h<strong>and</strong>, if blood calcium levels become too high, the thyroid gl<strong>and</strong> releases<br />

calcitonin, which inhibits the release of calcium from the bone <strong>and</strong> increases calcium<br />

excretion from the kidneys. These mechanisms help to restore normal blood calcium<br />

concentrations, after which calcitonin levels drop again.

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