Tobacco and Public Health - TCSC Indonesia

Table 5.3 (continued) Representative DNA adducts of some cigarette smoke carcinogens and related compounds. Occurrence and likely consequent
mutations
Carcinogen a DNA Adduct b Detected in smokers’ Likely mutations Reference
base lung? (type of evidence) c
1,3-Butadiene G 7 CH2CHCH CH2 No d (Koc et al. 1999;
OH
Tretyakova et al. 1997)
7
CHCH CH 2
G No d (Koc et al. 1999;
CH2OH Tretyakova et al. 1997)
A 1 CH2CHCH CH2 No (Tretyakova et al. 1997)
OH
A 1 CHCH CH2 No (Tretyakova et al. 1997)
CH 2 OH
G 7 CH2CHCHCH2OH No d (Koc et al. 1999; Koivisto
OH OH
et al. 1999)
A 1 CH2CHCHCH2OH No (Zhao et al. 2000)
OH OH
G CH2CHCHCH2OH No GC→TA>GC→ (Carmical et al. 2000)
OH OH
AT>GC→CG
N 2
Acetaldehyde G N No GC→AT, AT→TA (Noori and Hou 2001;
2
CHCH 3
G O
No Wang et al. 2000a)
H 3 C
N 2
N
N
N
N
N
H dR
Crotonaldehyde G OH O
No (Chung et al. 1999)
H 3 C
N
N
N
N
N
H dR