Tobacco and Public Health - TCSC Indonesia

the DNA adducts resulting from tobacco carcinogen exposure have been characterized
in tissues from smokers. Other studies demonstrate convincingly that some of these
DNA adducts cause mutations during DNA replication. The observed mutations are
frequently similar to those seen in oncogenes and tumor suppressor genes isolated
from human lung cancers. Mutations in these genes lead to cancer by disrupting
normal cellular signaling processes that control growth. The studies summarized here
therefore demonstrate how cigarette smoke carcinogens—through human uptake,
metabolic activation, and induction of mutations—firmly link nicotine addiction to
cancer in smokers.
Acknowledgements
Research on tobacco and cancer in the author’s laboratory is supported by grants from
the US National Institutes of Health (CA-81301, CA-92025, CA-46535, ES-11297,
DA-13333) and the American Cancer Society (RP-00–138).
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