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Tobacco and Public Health - TCSC Indonesia

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776<br />

INDEX<br />

British Doctors’ Study (Continued)<br />

lung cancer 492<br />

mortality related to smoking 8–9, 10, 29–30<br />

pancreatic cancer 480<br />

Broin v. Philip Morris 688–9<br />

bronchitis<br />

childhood (acute) 300, 301<br />

chronic 28, 579<br />

see also chronic obstructive pulmonary disease<br />

bronchoconstriction, smoke-induced 581<br />

Brown <strong>and</strong> Williamson <strong>Tobacco</strong> 39<br />

cigarette advertising 42, 47–8<br />

Buerger’s disease 5<br />

bupropion 140, 740<br />

genetic influences on effects 633–4<br />

recommendations 754, 756<br />

burden due to tobacco<br />

central <strong>and</strong> eastern Europe 235<br />

India 260–1<br />

laryngeal cancer 377, 378<br />

Burkina Faso 268, 273<br />

burn rate, cigarette 171<br />

burns 652<br />

Burundi 275<br />

1,3-butadiene 55, 60, 96<br />

carcinogenicity 95–7<br />

DNA adducts 108, 111, 113<br />

cadmium 61, 97<br />

caffeic acid 61<br />

caffeine, vs nicotine 137<br />

California Environmental Protection Agency<br />

(CalEPA) 287, 289, 290, 298, 566<br />

Camel© 37, 45, 46, 661, 769<br />

Cameroon 272, 273<br />

campesterol 58<br />

Canada<br />

female smoking rates 332<br />

lung cancer 496<br />

machine smoking method 191–2<br />

smoking bans <strong>and</strong> restrictions 714<br />

tobacco control legislation 682–4, 697<br />

cancer<br />

burden in India 260–1<br />

childhood 299, 300<br />

genetic susceptibility 626, 634–7<br />

mechanisms of induction 93–4<br />

tobacco <strong>and</strong> alcohol interaction 647–51<br />

tobacco smoke carcinogens <strong>and</strong> 94–8<br />

in women 335<br />

see also specific types of cancer<br />

c<strong>and</strong>idate gene association studies 630–2<br />

capsaicin (VR1) receptors 174<br />

carboline 172<br />

carbon dioxide 55<br />

carbon monoxide (CO)<br />

cigarette smoke 55, 58, 65<br />

international comparison 188–9<br />

trends over time 75, 81–2, 187<br />

cigar smoke 194, 195<br />

expired air 757<br />

novel PREPs 198<br />

carcinogenesis 93–4<br />

role of alcohol 646<br />

steps in 635–7<br />

carcinogens<br />

smokeless tobacco 426<br />

tobacco smoke 93–125, 426, 635<br />

animal studies 53–4, 493<br />

cancer <strong>and</strong> 94–8<br />

cigarette design changes affecting 64–79<br />

detoxification 636<br />

DNA interactions 106–14<br />

dose estimation 99<br />

identification 59–61<br />

mechanisms of cancer induction 93–4<br />

metabolism 424–5, 635<br />

new types of cigarettes 78<br />

nicotine derived 182<br />

novel PREPs 197, 198, 199–200<br />

p53 <strong>and</strong> K-ras genes <strong>and</strong> 113–14<br />

regulatory control 663, 768–9<br />

studies in smokers 80–1<br />

urinary metabolites as biomarkers of uptake<br />

98–106<br />

cardiovascular disease (CVD) 549–76<br />

alcohol <strong>and</strong> tobacco interaction 651<br />

biological plausibility 565–6<br />

Bradford Hill criteria <strong>and</strong> 551–6<br />

consistency of association 560–2<br />

mortality trends 554–6<br />

passive smoking <strong>and</strong> 549–50, 566–8<br />

biological plausibility 565–6<br />

Bradford Hill criteria 567<br />

reversibility 563–4<br />

scope of literature discussed 550–1<br />

specificity of association 565<br />

strength <strong>and</strong> dose–response 556–60<br />

temporal sequence of association 562–3<br />

type of tobacco product <strong>and</strong> 569<br />

unanswered questions 568–70<br />

caries, dental 611, 612<br />

Carlton© 41–2<br />

β-carotene 472<br />

carotid artery occlusion 565<br />

case-control studies, (of 1950) 6–7, 20–1, 489,<br />

551–2<br />

cataracts 601–5, 613<br />

catechol 61<br />

cigarette smoke 57, 58<br />

trends over time 75<br />

catechol O methyl transferase (COMT) 631–2<br />

causal associations, Bradford Hill criteria 490, 550,<br />

551–6<br />

CD4/CD8 ratio 470–1<br />

cellulose acetate filters 65, 66<br />

smoke yields <strong>and</strong> 66–8, 81<br />

Central African Republic 273<br />

central <strong>and</strong> eastern Europe (CEE) 235–52<br />

lung cancer 486, 488, 494<br />

marketing to women 342

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