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Tobacco and Public Health - TCSC Indonesia

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588<br />

CHRONIC OBSTRUCTIVE PULMONARY DISEASE<br />

COPD with use of these cigarettes (NCI 2001). Whatever symptomatic benefits may<br />

occur, they are clearly dwarfed by the increases in disease risk that accrue with continued<br />

smoking.<br />

Summary<br />

Cigarette smoking is the dominant cause of chronic obstructive pulmonary disease for<br />

both men <strong>and</strong> women. Changes in the lungs of smokers can be demonstrated within a<br />

few years of beginning to smoke. By the age 25–34 years, evidence of functional loss is<br />

evident in populations of smokers. The risks of developing ventilatory impairment <strong>and</strong><br />

of dying of COPD increase with increasing number of cigarettes smoked per day <strong>and</strong><br />

increased duration of smoking. Cessation of smoking alters the rate of lung function<br />

decline <strong>and</strong> risk of dying from COPD, but the benefits of cessation are greatest when<br />

cessation can be achieved early before substantial lung injury has occurred.<br />

References<br />

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Effects of smoking intervention <strong>and</strong> the use of inhaled anticholinergic bronchodilator on the<br />

rate of decline in FEV1: the Lung <strong>Health</strong> Study. Journal of the American Medical Association,<br />

272, 1497–505.<br />

Auerbach, O., Hammond, E. C., Garfinkel, L., <strong>and</strong> Benante, C. (1972). Relation of smoking <strong>and</strong> age<br />

to emphysema. Whole-lung section study. New Engl<strong>and</strong> Journal of Medicine, 286, 853–7.<br />

Barnes, P. J. (2000). Chronic obstructive pulmonary disease. New Engl<strong>and</strong> Journal of Medicine,<br />

343, 269–80.<br />

Beck, G.J.,Doyle, C. A., <strong>and</strong> Schachter, E. N. (1981). Smoking <strong>and</strong> lung function. American Review of<br />

Respiratory Disease, 123, 149–55.<br />

Buist, A. S., Sexton, G. J., Nagy, J. M., <strong>and</strong> Ross, B. B. (1976). The effect of smoking cessation <strong>and</strong><br />

modification on lung function. American Review of Respiratory Disease, 114, 115–22.<br />

Buist, A. S., Nagy, J. M., <strong>and</strong> Sexton, G. J. (1979). The effect of smoking cessation on pulmonary function:<br />

a 30-month follow-up of two smoking cessation clinics. American Review of Respiratory<br />

Disease, 120, 953–7.<br />

Burns, D. M. (2000). Primary prevention, smoking, <strong>and</strong> smoking cessation—implications for future<br />

trends in lung cancer prevention. Cancer, 89,No. 11 (Suppl), 2506–9.<br />

Burrows, B., Knudson, R. J., Cline, M. G., <strong>and</strong> Lebowitz, M. D. (1977). Quantitative relationships<br />

between cigarette smoking <strong>and</strong> ventilatory function. American Review of Respiratory Disease,<br />

115, 195–205.<br />

Cosio, M. G., Chezzo, H., Hogg, J. C., Corbin, R., Lovelnd, M., Dosman, J., <strong>and</strong> Macklem, P. T. (1978).<br />

The relations between structural changes in the small airways <strong>and</strong> pulmonary function tests.<br />

New Engl<strong>and</strong> Journal of Medicine, 298, 1277–81.<br />

Cosio, M. G., Hale, K. A., <strong>and</strong> Niewoehner, D. E. (1980). Morphologic <strong>and</strong> morphometric effects<br />

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Higenbottam, T., Clark, T. J. H., Shipley, M. J., <strong>and</strong> Rose, G. (1980). Lung function <strong>and</strong><br />

symptoms of cigarette smokers related to tar yield <strong>and</strong> number of cigarettes smoked.<br />

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