Tobacco and Public Health - TCSC Indonesia

of carcinogens and toxins in its wake. Regulation by existing authorities responsible for
pharmaceutical regulation would seem sensible. The probable effect would be a considerable
simplification of the cigarette, with much smaller amounts, and smaller
variation in the amounts, of carcinogens and toxins in the inhaled smoke. Another
effect might be a significant diminution in the number of brands on the market.
References
NIGEL GRAY 771
Benowitz, N. L. and Henningfield, J. E. (1994). Establishing a nicotine threshold for addiction. The
implications for tobacco regulation. N Engl J Med , 331, 123–5.
Borgerding, M. F., Bodnar, J. A., and Wingate, D. E. (2000). The 1999 massachusetts Benchmark
study—the final report. Conducted for the Massachusetts Department of Public Health by the
Tobacco Industry. Massachusetts Department of Public Health, Massachusetts.
Bross, I. D. and Gibson, R. (1968). Risks of lung cancer in smokers who switch to filter cigarettes.
Am J Public Health Nations Health, 58, 1396–403.
Cox, J. D. and Yesner, R. A. (1979). Adenocarcinoma of the lung: Recent results from the Veterans
Administration Lung Group. Am Rev Respir Dis, 120, 1025–9.
Djordjevic, M. V., Fan, J., Ferguson, S., and Hoffmann, D. (1995). Self-regulation of smoking
intensity. Smoke yields of the low-nicotine, low-‘tar’ cigarettes. Carcinogenesis, 16, 2015–21.
el-Torky, M., el-Zeky, F., and Hall, J. C. (1990). Significant changes in the distribution of histologic
types of lung cancer. A review of 4928 cases. Cancer, 65, 2361–7.
Fischer, S., Spiegelhalder, B., and Preussmann, R. (1990). Tobacco-specific nitrosamines in European
and USA cigarettes. Arch Geschwulstforsch, 60, 169–77.
Gourlay, S. G. and Benowitz, N. L. (1997). Arteriovenous differences in plasma concentration of
nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal
spray, and intravenous nicotine. Clin Pharmacol Ther, 62, 453–63.
Gray,N.and Boyle, P. (2002). Regulation of cigarette emissions. Ann Oncol, 13, 19–21.
Gray,N., Zaridze, D., Robertson, C., Krivosheeva, L., Sigacheva, N., and Boyle, P. (2000). Variation
within global cigarette brands in tar, nicotine, and certain nitrosamines: analytic study.
Tob Control, 9, 351.
Hammond, E. C., Garfinkel, L., Seidman, H., and Lew, E. A. (1976). ‘Tar’ and nicotine content of
cigarette smoke in relation to death rates. Environ Res, 12, 263–74.
Hawthorne, V. M. and Fry, J. S. (1978). Smoking and health: The association between smoking
behaviour, total mortality, and cardiorespiratory disease in west central Scotland. J Epidemiol
Community Health, 32, 260–6.
Hoffmann, D. and Hoffmann, I. (2001). The changing cigarette: Chemical studies and bioassays.
In: Risks associated with smoking cigarettes with low machine-measured yields of tar and nicotine
(Anonymous), pp. 159–91. Bethesda: US Department of Health and Human Services, National
Institutes of Health, National Cancer Institute].
Jarvis, M. J., Boreham, R., Primatesta, P., Feyerabend, C., and Bryant, A. (2001). Nicotine yield from
machine-smoked cigarettes and nicotine intakes in smokers: Evidence from a representative
population survey. J Natl Cancer Inst, 93, 134–8.
Johnson, W. W. (1988) Histologic and cytologic patterns of lung cancer in 2580 men and women over
a 15-year period. Acta Cytol, 32, 162–8.
Kessler, D. A., Witt, A. M., Barnett, P. S., Zeller, M. R., Natanblut, S. L., Wilkenfeld, J. P., Lorraine, C. C.,
Thompson, L. J., and Schultz, W. B. (1996) The Food and Drug Administration’s regulation of
tobacco products. N Engl J Med, 335, 988–94.