Literature review for - Flourish Paediatrics

Effect on risk
gastric emptying rates and
any of the indices of
gastroesophageal reflux over 24
hours (Pearson correlation
coefficient = 0.05),
There was no correlation between
feed volume and reflux index
(Pearson correlation coefficient =
0.05),
Gastric emptying time is not a
determinant of asymptomatic
gastroesophageal reflux.
Gastroesophageal reflux was also
unrelated to feed volume and feed
type.
Authors postulate that inappropriate
relaxation of the lower oesophageal
sphincter or abnormal oesophageal
motility offer more plausible
explanations
3.0 (1.6,5.2) compared with 8.3
(5.0,13.3) min/h of active sleep
respectively.
The lower median pH values for GOR
in breastfed neonates (2.0) vs formula
fed infants (2.5) were significantly
different.
The volume of milk was unrelated to
either the number or duration of reflux
episodes.
Authors hypothesis that the lower pH
value observed in breastfed infants
could reflect more rapid gastric
empting. The low pH is more likely to
stimulate peristalsis and thus reduce
the duration of reflux.
Results suggest that feed type is an
important variable to consider in
evaluating GER.
Clinical 4 4 4
importance
Clinical 1 1 1
relevance
Generalisability Y – UK Y Y – US
Applicability Y – UK Y Y- US
Regurgitation is common in infancy, and
occurs most frequently in infants 3-6
months of age.
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