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Literature review for - Flourish Paediatrics

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of upper respiratory infectionRR 0.82<br />

(95% CI 0.52 -1.29) (outcome 51) or of<br />

one or more episodes of lower<br />

respiratory tract infection (RR 1.07<br />

(95%CI 0.86-1.33) (outcome 52).<br />

Kramer 2000a found a small and<br />

nonsignificant reduction in risk of 2 or<br />

more respiratory tract infections (upper<br />

and lower combined) RR 0.90 (95% CI<br />

0.79 -1.03) (outcome 53). The<br />

combined crude results of Oddy<br />

1999and Kramer 2000a show a<br />

substantial and statistically significant<br />

reduction in risk <strong>for</strong> hospitalization <strong>for</strong><br />

respiratory tract infection pooled RR<br />

0.75 (95% CI 0.60 -0.94), but the crude<br />

risk reduction in Kramer 2000a was<br />

nearly abolished and became<br />

statistically nonsignificant in a<br />

multivariate mixed model controlling<br />

<strong>for</strong> geographic region, urban vs rural<br />

location, maternal education and<br />

cigarette smoking, and number of<br />

siblings in the household adjusted OR<br />

0.96 (95% CI 0.71- 1.30) (outcome<br />

54).In a study from Tucson, Arizona,<br />

(Duncan 1993) reported no difference in<br />

the average number of episodes of acute<br />

otitis media in the first 12 mo of life<br />

(outcome 55) in the exclusive vs MBF<br />

groups (1.48 vs. 1.52 episodes,<br />

respectively) (95% CI <strong>for</strong> the difference<br />

510

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