Literature review for - Flourish Paediatrics

eflux index, number of acid
gastroesophageal reflux episodes per
hour, or number of reflux episodes
lasting >5 minutes but significantly
reduced the duration of the longest
reflux episode of pH < 4 -8.09 [-11.93
to -4.25] (P < .0001).
No definitive data showed that one
particular thickening agent is more
effective than another.
No serious adverse effects were noted.
No evidence that the thickened foods
differed from the control formulas in
terms of safety.
Effect on risk Thickening foods are only moderately
effective in treating GER in otherwise
healthy infants. definitive data to show
that a particular thickening agent is
more effective than another.
No difference in effect. There are risks
associated with the use of lansoprazole.
Authors suggest physicians that feel
treating GOR is important to choose a
thickening agent based on patient’s
preference, cost, product availability.
Clinical 4 1 1
importance
Clinical 1 1 1
relevance
Generalisability Y Y Y– US & Poland
Applicability Y Y Y – US & Poland
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