Literature review for - Flourish Paediatrics

11 EGGS (S1.1)
EGGS and CORONARY HEART DISEASE
Does a particular intake of eggs affect the risk of coronary heart disease in adults?
Evidence statement
Grade
Component Rating Notes
Consumption of eggs daily is not associated with increased
risk of coronary heart disease
B
Evience Base Excellent 13 level II trials (RCTs – mostly positive studies, only 3
neutral studies), 1 level III-1 study (positive) and 5 level
III-2 studies (1 neutral, remainder positive). 2 crosssectional
and 1 pre-test post test study not extracted.
Consistency Good Fairly consistent that there is no effect of egg consumption
on risk of CVD (15 No Effect (11 RCT studies, 1 III-1
study, 3 cohort studies); 4 showed increased risk (2 cohort
studies and 2 RCT showed slight increases in one measure
of blood lipids).
Clinical impact Poor Majority of ORs cross 1 or p value not significant for
differences between groups for RCTs.
Generalisability Good Populations in body of evidence relevant to adults of most
ages and genders and also include Australian Aborigines,
infants and older people.
Applicability Excellent Directly applicable to Australian healthcare context
One of the thirteen trials used to develop the body of evidence statement for eggs and coronary heart
disease was conducted on infants.
Study used to make evidence statement for eggs (in infancy) and coronary heart disease
Makrides 2002
Block RCT
II
7 mth intervention and either:
1) Four n-3 egg yolks per wk;
2) Four regular egg yolks per wk;
3) no dietary intervention/ blood lipids
44-47
6 mth old Australian infants born at term with birth wts >2.5 kg and no known protein intolerances or
463