Literature review for - Flourish Paediatrics

Table 18.2 Studies used to make evidence statement for life course food consumption and breastfeeding.
Reference [1] Owen 2005 Owen 2005
Type of study [2]
Meta analysis of 4 historical cohort, 13 prospective
cohort, 2 case-control, 10 cross-sectional studies
Meta-analysis of 17 prospective cohort, 2
historical cohort, 13 cross-sectional studies)
Level of evidence [3] I I
Intervention/ comparator [4] Association between infant feeding and development
of obesity later in life
Association between infant feeding and mean
BMI (absolute) later in life
N [5] 672 161 Not provided
Population/study information
[6]
Children born 1946-1996, most followed through
childhood or adolescence, with 2 studies following
through early adulthood (age 33 yrs maximum);
Canada, UK, Germany, Sweden, Czech Republic,
China, Turkey, Australia, New Zealand, Italy, Slovak
Republic, USA.
Quality [7] 0 0
Results [8]
Breastfed subjects were less likely to be defined as
obese than were formula-fed infants OR 0.87 (95%
CI 0.85-0.89). All individual studies reported some
protective effect of breastfeeding, but not all were
significant. Definition of obesity varied among
studies.
Effect on risk
Protect
(Increase/None/Protect)
Clinical importance [9] 1 2
Clinical relevance [10] 2 2
Generalisability y y
Applicability y y
6-week-old infants followed minimum of 1 yr,
maximum of 70yrs; USA, The Netherlands,
Italy, UK, Germany, Denmark, Australia, New
Zealand, China, Czech Republic, Brazil.
This study found lower mean BMIs in subjects
who had been breastfed in infancy than in those
who had been formula-fed in the crude analysis
(difference in BMI -0.04 (95% CI -0.05 to -
0.02). This small effect was halved by
adjustment for maternal BMI in early life and
became non-significant with meta-analysis of 11
studies that simultaneously adjusted for maternal
BMI, maternal SES, and maternal smoking.
None
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