Literature review for - Flourish Paediatrics

finally recruited.
Outcome measure was a
physician’s diagnosis of
atopic eczema within 6 and
18 months
Blood samples at 8 years
and specific IgE
components measured.
Quality P/N/0 N P P P
Results
EBF for >4 months
associated with lower rates of
asthma at three years
Adjusted OR 0.69(0.6-0.96)
Adjusted odds ratios
< 4 months (n=847 )1.00
(Reference)
4–6 months (n=16,045) 1.11
(0.80, 1.53) p=0.539
>6 months (n=1881)1.08
(0.74, 1.57) p=0.698
Breastfeeding is associated
with a lower asthma risk in
children until 8 years of age
without evidence of
attenuation and regardless
of the family history of
allergy
Adj OR by length of ABF
Asthma
1-16 weeks 0.82 (0.61, 1.09)
>16weeks 0.57 (0.41, 0.80)
Chronic Asthma
1-16 weeks 0.87 (0.62, 1.24)
>16weeks 0.57 (0.41, 0.80)
Carolina Hospitals.
Singleton pregnancies.
Interviewed at 3 and 12
months post partum. 92%
initiated breastfeeding
Meta-Analysis of
prospective cohort studies
of the association between
asthma risk and
breastfeeding ≥ 3 months
for children with positive
family history of asthma or
atopy (excluding Wright
2001)
OR 0.60 (0.43, 0.82)
Meta-Analysis of
prospective cohort studies
of the association between
asthma risk and
breastfeeding ≥ 3 months
for children with positive
family history of asthma or
atopy (including Wright
2001)
OR 0.81 (0.41, 1.60)
NOTE: The heterogeneity
can be explained by a single
study. Compared with the
other studies in the analyses,
the age of follow-up was 13
400