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Literature review for - Flourish Paediatrics

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England.<br />

After the birth, a short<br />

questionnaire was completed<br />

by the parents to ascertain<br />

in<strong>for</strong>mation regarding their<br />

newborn. At each of the 6-, 12-<br />

, 18-, 24-, and 36-month<br />

follow-up contacts the parents<br />

of each offspring were<br />

instructed to complete a more<br />

in-depth questionnaire about<br />

the child’s living environment<br />

and feeding habits.<br />

In<strong>for</strong>mation on asthma and<br />

wheezing was provided<br />

by parents at four follow-ups<br />

(12, 18, 24, and 36 months).<br />

selected.<br />

Mother’s on infants were<br />

visited at home when infant<br />

was 7 months old. Infants<br />

were categorised into BM or<br />

BCM on day 0 of the study<br />

according to mothers recall.<br />

Of 62 infants, 35 were<br />

categorised into the BM<br />

group (receiving only<br />

breastmilk with or without<br />

solids) an 27 were<br />

categorised into the BCM<br />

group (receiving cow’s milk<br />

in addition to breastmilk with<br />

solids)<br />

Breast-milk intake was<br />

measured using deuterium<br />

oxide, complementary food<br />

intake by 1-d food weighing,<br />

total energy expenditure and<br />

total body water using doubly<br />

labeled water; anthropometric<br />

indices were also calculated<br />

from age 9 months to<br />

2 years.<br />

Dietary intake was<br />

determined using<br />

estimated diet records at 9,<br />

12, 18 and 24 months<br />

of age<br />

In both cohorts; growth<br />

data were collected at<br />

healthcare centres. Dietary<br />

consumption was recorded<br />

throughout the first year<br />

(once monthly). Weighedfood<br />

records <strong>for</strong> 2 days at<br />

2, 4, 6, 9 and 12 months of<br />

age and <strong>for</strong> 3 days at 2 and<br />

6 years of age were used in<br />

the analysis of food and<br />

nutrient intake. Blood<br />

samples were taken<br />

at 1, 2 and 6 years of age<br />

<strong>for</strong> analyses of Hb,<br />

serum ferritin (SF), serum<br />

transferrin receptors, mean<br />

corpuscular volume<br />

(MCV) and erythrocyte<br />

distribution width<br />

Icelandic Developmental<br />

Inventory (evaluates the<br />

motor and verbal<br />

development of children<br />

aged 3–6 years) was<br />

completed by the mothers<br />

of seventy-seven<br />

participants from cohort 1,<br />

but as there were only<br />

thirty-six participants from<br />

382

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