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Literature review for - Flourish Paediatrics

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from 8 - 12 months (outcome three); the<br />

WMD was -1.82 (95% CI -16.72 to<br />

+13.08) g/mo, which excludes a<br />

reduced length gain in the EBF group of<br />

5% of the mean and 10% of the SD <strong>for</strong><br />

the Belarussian study. For length gain at<br />

3 - 8 months (outcome four), the studies<br />

again show significant (P < .01)<br />

heterogeneity. Kramer 2000a found a<br />

slightly but significantly lower length<br />

gain in the EBF group at 4 - 8 months<br />

(difference -1.1 (95% CI -1.7 to - 0.5)<br />

mm/mo), whereas the pooled analysis<br />

yielded a WMD of - 0.4 (95% CI -0.7 to<br />

0.0) mm/mo; the lower confidence limit<br />

is statistically compatible with a<br />

reduced length gain of less than 4% of<br />

the mean and 10% of the SD <strong>for</strong> the<br />

Belarussian study. Heinig 1993 and<br />

Kramer 2000a also reported on length<br />

gain at 6 - 9 months (WMD -0.4 (95%<br />

CI -1.0 to +0.1) mm/mo) (outcome<br />

five). For the 8 -12 moh period, the<br />

results show a slightly but significantly<br />

higher length gain in the EBF group<br />

(WMD+0.9 (95% CI +0.3 to +1.4))<br />

mm/mo (outcome six). Observational<br />

analyses from the Belarussian study<br />

(Kramer 2000a) also include data on<br />

weight-<strong>for</strong>-age, length-<strong>for</strong>-age, and<br />

weight <strong>for</strong> length z-scores at six, nine,<br />

and 12 mo. Means in both the EBF and<br />

compared with partial was reported in 1<br />

study and a further study showed that<br />

HIV-free survival did not differ in<br />

infants who were HIV-negative at 4 mo<br />

and were abruptly weaned or continued<br />

to be breastfed. Authors created a<br />

cohort model of child mortality and<br />

stunting by modelling the survival and<br />

linear growth status of the annual birth<br />

cohort of children from birth until 3 yrs<br />

in 36 countries with 90% of the global<br />

burden of stunted children. In children<br />

aged 6-23 mo the baseline breastfeeding<br />

category is breastfed (RR 1.0) vs non<br />

breastfed (RR 2.3). using this model,<br />

authors reported that mortality risk ratio<br />

<strong>for</strong> exclusive breastfeeding (age

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