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Literature review for - Flourish Paediatrics

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Overall quality<br />

assessment<br />

(Positive/Negative or<br />

Neutral) plus<br />

descriptive)<br />

RESULTS<br />

Outcome<br />

EXTERNAL<br />

VALIDITY<br />

Generalisability<br />

Applicability<br />

Comments<br />

Conclusion<br />

Negative but summarising previously published systematic <strong>review</strong> and giving a guide to interpretation of the studies<br />

Odds ratios in the range of 1.2 to 1.5 <strong>for</strong> increased risk of asthma and atopic disease all show increased risk when not<br />

breastfed. Authors quote a previously published meta-analysis of 9 studies showing that children breastfed <strong>for</strong> at least<br />

3 months were significantly protected against development of asthma, OR= 0.80 and other meta analyses with a<br />

similar protective effect (26%-30%) <strong>for</strong> exclusive breastfeeding during the first 3 months from developing asthma,<br />

allergic rhinitis and atopic eczema.<br />

y<br />

y<br />

All studies that met the strict criteria <strong>for</strong> breastfeeding and atopic disease demonstrated a protective effect of breastmilk<br />

or, conversely, a risk with <strong>for</strong>mula feeding. However, the continuing protective effect of breastfeeding on asthma<br />

and atopy later in adolescence and adulthood has yet to be confirmed in larger longitudinal studies. Given the many<br />

benefits conferred by breast-milk, breastfeeding should continue to be promoted as the preferred infant feeding<br />

method <strong>for</strong> the first 6 months and up to two years, as recommended by WHO.<br />

398

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