Literature review for - Flourish Paediatrics

excluded.
from the Denver
metropolitan area (n = 501).
70% non-Hispanic white,
23% Hispanic. Followed
from birth till mean age of
4.7 yrs.
Quality [7] P P P N
Results [8]
An inverse association was
observed in analyses based
on age at introduction of
fish. Children introduced
to fish between 3-8 mo of
age had a reduced risk for
asthma OR 0.73 (95% CI
0.55–0.97), eczema (OR
0.77, 0.64–0.92), allergic
rhinitis (OR 0.77, 0.60–
0.97), and sensitization to
food and airborne allergens
(OR 0.78, 0.64–0.95) at
age 4 yrs compared with
children introduced to fish
at 9 mo or older. Fish
consumption of 2-3 times
per month at age 12 mo is
associated with reduced
risk of allergy at age 4 yrs:
Asthma OR 0.82 (0.54-
1.29), eczema OR 0.71
(0.53-0.95), allergic
rhinitis OR 0.51 (0.35-
0.73), at least one allergic
Delaying initial exposure to
cereal grains until after 6
mo significantly increase
the risk of developing wheat
allergy at mean age of
4.7yrs (OR: 3.8, 95% CI
(1.18-12.28)), after
adjusting for breastfeeding
duration, introduction of
rice cereal, family history of
allergy, and history of food
allergy before 6 mo of age.
The timing of rice-cereal
introduction was not
significantly associated with
wheat allergy after
adjustment for cereal-grain
exposure, breastfeeding
duration, and family history
of allergy.
No specific data was reported
on association with delayed
introduction of solids and risk
of asthma or atopy.
Evidence of a link between
the early introduction o solid
foods in general and the
onset of atopy is conflicting
and inconsistent. Evidence
as to an optimal time for the
introduction of any
individual solid food in the
infant’s diet is lacking. The
introduction of solid foods is
not an ideal research end
point because its full benefit
depends on the duration of
breastfeeding. But, authors
recommend: (1) Exclusion
of supplemental foods is
indicated during the first 6
months of life because if has
a preventative effect against
the onset of allergic
symptoms. (2) The
introduction of supplemental
foods during the first 4
months of life has been
associated with a higher risk
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