Literature review for - Flourish Paediatrics

(1 study overlaps with Bhola &
McGuire’s SLR)
reaction) test performed in
the first 3 days of life; 17
were positive, and 37 were
negative.
than 100
(1 study overlaps with
Yeung et al’s SLR)
(6 studies were also
reviewed in Pembery et
al’s SLR)
local databases.
Received information of
1,655 mother-child pairs.
181 mother-child pairs. Of
the 1,474 hepatitis C virus
infected women that
remained, 503 (35%) were
co-infected with HIV
Quality P 0 0 0
Results
Rates of mother-to-infant
transmission between
breastfedand non–
breastfedinfants were similar.
The weighted rate of motherto-infant
transmission was
3.7% and 3.9% for breastfed
and non-breastfedinfants,
respectively (crude rate 6.0%,
SD = 1.1% and 6.3%, SD =
0.8% for breastfedand
nonbreastfed
infants, respectively).
Breastfedinfants were
less likely to be PCR positive
in the first 3 days of life than
formula fed infants. Authors ?
significance of association
due to small numbers
involved.
38% formula fed infants were
PCR positive in the first 3
days postpartum compared to
9% of breastfed infants.
No studies found a
difference in the rate of
transmission between
infants fed with
breastmilk and those fed
with formula.
Although some investigators
have detected HCV RNA in
breast milk, no definite case of
mother-to-infant transmission
of HCV via breastmilk has
been reported.
Unadjusted OR = 0.16 (0.02,
1.52)
Among the women with
hepatitis C virus infectiononly,
multivariate analyses
did not show a
significant effect of
breastfeeding; breastfed
versus non-breastfed OR =
1.07 (0.57,2.02) (P =
0.83). However, HIV coinfected
women
who breastfed were about
four times more likely to
infect their children than
those who did not OR =
6.41 (1.25,32.94) (P =
0.03).
Effect on risk Breastfeeding does not Although the risk of Avoidance of Breastfeeding increasing
349