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Literature review for - Flourish Paediatrics

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eported a reduced risk of a history<br />

of food allergy (outcome 32), double<br />

food challenges showed no<br />

significant risk reduction RR 0.77<br />

( 95% CI 0.25-.41) (outcome<br />

33).Neither Oddy 1999 nor Kramer<br />

2000a found a significant reduction<br />

in risk of recurrent (two or more<br />

episodes) wheezing in the EBF group<br />

pooled RR 0.79 (95% CI 0.49 -1.28)<br />

(outcome 34). In the Kajosaari 1983<br />

study, the reduction in risk of any<br />

atopy at five years (outcome 35) in<br />

the EBF group was nonsignificant<br />

RR 0.68 (95% CI 0.40 -1.17), and no<br />

reduction in risk was observed <strong>for</strong><br />

atopic eczema RR 0.97 (95% CI 0.50<br />

-1.89) (outcome 36). A reduction in<br />

risk of borderline significance was<br />

observed <strong>for</strong> pollen allergy at five<br />

years RR 0.53 (95% CI 0.28- 1.01)<br />

(outcome 37). Both Kajosaari 1983<br />

and Oddy 1999 reported on risk of<br />

asthma at 5-6 years (outcome 38);<br />

the pooled RR was 0.91 (95% CI<br />

0.61-1.36). Reduced risks of history<br />

of food allergy RR 0.61 (95% CI<br />

0.12- 3.19) (outcome 39) and allergy<br />

to animal dander RR 0.81 (95% CI<br />

0.24 - 2.72) at five years (outcome<br />

40) were far from achieving<br />

statistical significance. Oddy 1999<br />

547

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