Literature review for - Flourish Paediatrics

2000a and a cohort study from Finland
(Kajosaari 1983) reported an atopic
eczema at one yr (outcome 31). The two
studies showed statistically significant
(P= .03) heterogeneity, with Kajosaari
1983 reporting a significantly reduced
risk RR 0.40 (95% CI 0.21 to 0.78), but
the larger Belarussian study finding a
much lower absolute risk in both
feeding groups and no risk reduction
with EBF RR 1.00 (95% CI 0.60 to
1.69). Although Kajosaari 1983 also
reported a reduced risk of a history of
food allergy (outcome 32), double food
challenges showed no significant risk
reduction RR 0.77 (95% CI 0.25 -2.41)
(outcome 33). Neither Oddy 1999 nor
Kramer 2000a found a significant
reduction in risk of recurrent (2 or more
episodes) wheezing in the EBF group
pooled RR 0.79 (95% CI 0.49 -1.28)
(outcome 34). In the Kajosaari 1983
study, the reduction in risk of any atopy
at five years (outcome 35) in the EBF
group was nonsignificant RR 0.68 (95%
CI 0.40 -.17), and no reduction in risk
was observed for atopic eczema RR
0.97 (95% CI 0.50 - 1.89) (outcome 36).
A reduction in risk of borderline
significance was observed for pollen
allergy at five years RR 0.53 (95% CI
0.28-1.01) (outcome 37). Both
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