Literature review for - Flourish Paediatrics

Table 24.1 Summary used to make evidence statements for breastfeeding and adult disease onset.
STUDY DETAILS
(Review)
Reference
Affiliation/source of
funds
Study design
Level of evidence
Owen et al. 2008
University of London, University of Bristol, Umea University, Royal Free and University College Medical School,
University of Southhampton, Southhampton General Hospital, State University of new York, The George Institute Sydney,
Children's Hospital Zagreb, John Radcliffe Hospital Oxford, Turku University Central Hospital, University of Amsterdam,
University of Otago; Supported by the British Heart Foundation Project
Meta Analysis (4 cross sectional, 2 historical cohort, 10 prospective cohort, 1 retrospective cohort)
III-2 Evidence obtained from comparative studies (including systematic reviews of such studies) with concurrent controls
and allocation not randomised, cohort studies, case-control studies, or interrupted time series with a control group.
Date of search 1950 to 2007
Number of studies 17
Total number of 17 498 (12 890 breastfed, 4608 formula fed)
participants
Population
characteristics
Range of exposure
Length of follow-up
Outcome(s)
measured
INTERNAL
VALIDITY
Databases included
in search
Statistical analysis
methods
Overall quality
assessment
(Positive/Negative
Formula and breast fed infants followed up until 17 - 71 yrs; in 7 studies it was possible to compare groups of subjects who
were exclusive breastfeeders and bottle feeders, in the remaining 10 studies the infant feeding groups were not completely
exclusive Northern Europe, Eastern Europe, USA, South America, New Zealand
Initital infant feeding practices
16 to 71 years
PRIMARY: 1. Concentrations of total blood cholesterol in adult life
Medline, Embase, Web of Science
Fixed effect models, mean difference, SE, chi-squared tests, meta-regression and sensitivity analysis
P
497