Literature review for - Flourish Paediatrics

9 FISH (S1.1)
Data was extracted from papers for the following outcomes but there was inadequate evidence base to
create body of evidence statements.
Fish and Allergic Disease
A cohort study was conducted on Swedish infants (Alm et al. 2009).
The Swedish study used self reported eczema and found Odds ratio (95% CI) of eczema for age at
introduction of fish
Gp 1: 1.1 (0.4-2.9); Gp 2: 0.7 (0.6-0.9); Gp 3: 0.6 (0.5-0.7); Gp 4: 1 (Ref)
Odds ratio (95% CI) eczema for frequency of fish consumption
Gp 1: 1 (Ref); Gp 2: 0.88 (0.64-1.20); Gp 3: 0.86 (0.62-1.20); Gp 4: 1.32 (0.86-2.02); Gp 5: 2.73 (1.80-
4.13)
Odds ratio (95% CI) eczema for usually eats lean fish, 0.81 (0.68-0.97).
Fish and Infant Cognition
There were three cohort studies examining fish consumption and infant cognitive outcomes. The VIVA
cohort of 135 mother-infant pairs found that Each extra fish serve/wk was associated with higher visual
recognition memory (VRM) score 2.9 (95%CI 0.2 to 5.4). When mercury was added to the model as a
potential confounder, this VRM score increased to 4.0 (95%CI 1.3 to 6.7) points higher (Oken et al.
2005).
Two studies reported outcomes from the AVON cohort. The first in 7421 mother-infant pairs examined
the relationship between fish consumption and validated developmental questionnaires at 15 and 18
months. The found an OR of 0.7 for low test score and 1.4 for language for high scores, with some
items significant, and with a significant P for increasing consumption of fish. The second in 8764 at the
6mth follow-up and 5000 at the 8 year old follow-examined fish consumption against validated scale
domains for gross motor, fine motor, communication, and social skills, completed by parents when their
child was 6, 18, 30 & 42 mths at follow-up. Significant OR were found for full IQ and verbal ability
with a significant P for increasing consumption of fish.
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