Literature review for - Flourish Paediatrics

myenteric plexus
Quality P P N
Results
Between baseline and week 3, the
median daily frequency of
regurgitation decreased from 6.22 to
1.45 in the cisapride group, and from
4.80 to 1.35 in the domperidone
group.
Daily spilling was highest during the
first month of life (73%) and
decreased gradually to 50% during the
fifth month of life.
Although there was no difference in
the frequency of regurgitation
between the groups at baseline, week
2 and week 3, the frequency was
lower in the cisapride group on week
1.
The median RI decreased in the
cisapride group from 3.60% to
1.75%, and in the domperidone
group only from 2.70% to 2.45%
One child treated with cisapride
developed a significant QT
prolongation.
During the first 2 months of life, 20%
of the infants regurgitated
more than four times per day.
After the age of 12 months, 4% of the
infants had daily regurgitations.
Exclusively breastfed infants
regurgitated less than partially
breastfed infants. The difference is
statistically significant at 2, 3 and 6
months.
Weight gain between birth and
4 months of age was statistically
significantly smaller in infants
regurgitating more than four times a
day (2903 g) compared with infants
who never regurgitate (3015 g)
Their author’s previous prospective study
revealed a risk ratio of 4.5 (1.3,15.4).
Their case-control study obtained an odds
ratio of 3.5 (1.6,7.5)
The authors estimated that advice to
place infants supine to sleep may have
saved in the order of 850 infants annually
in Australia and other countries.
Effect on risk The clinical efficacy of domperidone Regurgitation in infancy is common, The prone sleep position is associated
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