Literature review for - Flourish Paediatrics

There was no significant association
between total crying duration per 24
hours and FRT (P=0.84) or the
number of reflux episodes (P=0.68).
There was no association between
back-arching and acid reflux.
No difference was observed in regards
to type of feeding and regurgitation.
Paediatricians suggested a change in
feeding method in 414/664 (62.3%)
infants with regurgitation
Effect on risk
Authors concluded that in the
absence of frequent regurgitation or
feeding difficulties a direct causal
relationship between persistent infant
distress and pathological GOR is
unlikely.
There was an increase in the prevalence
of eosinophilic oesophagitis between
1995 and 2004. Author’s note that
although this may be partially
accounted for by diagnostic shift and
increasing awareness of the significance
of mucosal eosinophilia, there was also
an increase in severity of inflammation,
with increasing eosinophil count and
associated features of inflammation in
oesophageal biopsy specimens over the
study period.
Regurgitation is common in infants
during the first 6 months after birth.
Results from the study suggest low birth
weight and low gestational age is
associated with the onset of
regurgitation and feeding habits do not
influence the onset of regurgitation.
Clinical 1 4 4
importance
Clinical 1 1 1
relevance
Generalisability Y Y Y
Applicability Y Y Y
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