Literature review for - Flourish Paediatrics

Table 20.2 Studies used to make evidence statement for age of introduction of solid foods and allergic syndromes (cont.)
Reference [1] Kull 2006 Poole 2006 Becker 2004 Fiocchi 2006
Type of study [2] Cohort Cohort RCT Systematic review of 11
prospective studies
Level of II II II I
evidence
Intervention/
comparator [4]
N [5]
Population/study
information [6]
Association between fish
consumption during the
first year of life and
development of allergic
diseases by age 4yrs.
4089 at baseline
3670 at follow-up
2614 for analysis
Children born in 1994-96
in Stockholm, Sweden,
from the Children, Allergy,
Milieu, Stockholm,
Epidemiological survey
[BAMSE], followed from
birth until age 4 yrs.
Healthy infants only -
those with eczema or
recurrent wheeze during
the first year of life were
Association between cerealgrain
exposures (wheat,
barley, rye, oats) in the
infant diet and development
of wheat allergy.
1819 at baseline
1612 at follow-up and for
analysis.
US Children born in 1993–
2004, from the Diabetes
Autoimmunity Study in the
Young [DAISY]. Identified
by either newborn screening
for HLA genotype at St
Joseph’s Hospital in
Denver, Colorado, US (n =
1111), or first-degree
relatives of individuals with
type 1 diabetes mellitus
Avoidance of house dust
mite, pet al.lergen and
tobacco smoke plus
breastfeeding, and delayed
introduction of solid foods
with control (nothing).
Dependent variable is
development of asthma or
atopy.
Intervention= 278 but data
only obtained for 246.
Control=267 but data only
obtained for 230.
Children born with high risk
of developing asthma based
on immediate family history.
Canada.
Relationship between
introduction of solids and
development of allergy
Number of subjects not
provided; 11 studies
examining allergic risk with
timing of intro of solid
foods.
Not provided, but assume it
includes western
populations. Healthy vs
high risk population not
reported in study.
491