Literature review for - Flourish Paediatrics

positioning strategies.
The treatment period included
randomization to either lansoprazole or
a placebo. After one week of double
blind treatment infants discontinuing
treatment due to inefficiency were
eligible for open label lansoprazole.
Symptoms of GOR was collected
through daily diaries and weekly visits.
A parent completed questionnaire on
GOR measured the symptoms the
infants had.
Post-treatment involved telephone calls
and a follow up visit.
Quality N P P
Results Use of thickened formulas
compared with standard formula
significantly increased the percentage of
infants with no regurgitation RR= 2.91
(1.73,4.91), slightly reduced the number
of episodes of regurgitation and
vomiting per day RR = -1.37 (-2.53, -
0.20], and increased weight gain per day
(4 RCTs, Weighted MD: 3.55 g/day
[2.6 ,4.5],in fixed-effects model, and 3.7
g/day [1.55, 5.80], in random-effects
model)
Thickened formula had no effect on the
Lansoprazole and placebo produced
identical responder numbers (54%). The
treatment groups did not differ
significantly in terms of an secondary
efficacy measure.
Serious adverse events particularly
respiratory tract infections occurred in
10 infants on lansoprazole compared to
2 in the placebo group.
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