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Literature review for - Flourish Paediatrics

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eastfed<br />

Fe intake was inadequate <strong>for</strong><br />

9% of 9 month old infants not<br />

breastfed<br />

Children with one antibody<br />

positive; introduction of<br />

cow’s milk (months) = mean<br />

10.9±0.04, median 12<br />

Children with two or more<br />

antibody positive;<br />

introduction of cow’s milk<br />

(months) = mean 10.0±0.09,<br />

median 10.5<br />

Children antibody negative;<br />

introduction of cow’s milk<br />

(months) = mean 10.5±0.03,<br />

median 11<br />

infants who were fed with<br />

cow’s milk (30/64 46.9%).<br />

p= 0.449.<br />

The comparison of body<br />

iron indicators in<br />

accordance to positive or<br />

negative occult fecal<br />

blood, did not show any<br />

significant difference in<br />

the breastfed group. Serum<br />

ferritin was significantly<br />

lower (p=0.004) in infants<br />

who received cow’s milk<br />

and were positive <strong>for</strong><br />

occult fecal blood.<br />

Effect on risk<br />

A portion of Australian infants<br />

had a weaning diet low in Fe<br />

indicating the need to further<br />

emphasis delaying cow’s milk<br />

until 12 months of age.<br />

Results showed no<br />

prospective association<br />

between introduction of<br />

cow’s milk and the<br />

development of islet<br />

autoimmunity in high risk<br />

children.<br />

The data does not indicate<br />

an association between<br />

early exposure to cow’s<br />

milk and later<br />

development of IDDM.<br />

Clinical 4 1 4 1<br />

importance<br />

Clinical 1 1 1 1<br />

relevance<br />

Generalisability Y Y Y-Iran Y- Brazil<br />

Applicability Y Y Y-Iran Y- Brazil<br />

In infants fed whole cow’s<br />

milk occult fecal blood<br />

loss in an aggravating<br />

factor of iron deficiency.<br />

380

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