ELECTRONIC POSTER - ismrm

14:00 3645. Respiratory Self-Gated 2D Cine Balanced SSFP Myocardial Edema Imaging:
Preliminary Study in Canines
Swati Gupta 1 , Xiangzhi Zhou 2 , Xiaoming Bi 3 , Saurabh Shah 3 , Sven Zuehlsdorff 3 , Andrew
Larson 2 , Debiao Li 2 , Rohan Dharmakumar 2
1 Department of Biomedical Engineeering, Northwestern University, Chicago, IL, United States; 2 Department of
Radiology, Northwestern University, Chicago, IL, United States; 3 Siemens Medical Solutions, Chicago, IL,
United States
Myocardial edema imaging with bSSFP approaches have been recently demonstrated. In this work, we investigated the utility of
respiratory self-gated (RSG) 2D cine bSSFP for acquiring free-breathing myocardial edema images using a canine model subjected to
ischemia-reperfusion injury. Early results show that RSG bSSFP imaging is capable of generating edema contrast similar to breathheld
bSSFP imaging.
14:30 3646. Repair of Cardiac Damage Using Intrapericardial Drug Delivery by Means of MR-
Trackable Alginate Beads
Yamin Yang 1 , Marco L.H. Gruwel 2 , Patricia Gervai 3 , Jiankang Sun 3 , Olga Jilkina 1 ,
Eugene Gussakovsky 1 , Valery Kupriyanov 1
1 Cardiac, NRC-CNRC Institute for Biodiagnostics, Winnipeg, MB, Canada; 2 MRTechnology, NRC-CNRC
Institute for Biodiagnostics, Winnipeg, MB, Canada; 3 MRRD, NRC-CNRC Institute for Biodiagnostics,
Winnipeg, MB, Canada
Re-establishment of a vascular network is an important step in the repair of damaged myocardium. For this purpose vascular growth
factors were applied at the site of injury. To prolong action of these peptides, growth factors were incorporated in alginate beads.
However, visualization of the beads is not an easy task.
15:00 3647. Comprehensive and Serial Evaluation of Myocardial Structure, Function and
Perfusion in Reperfused Infarct
Maythem Saeed 1 , Alastair J. Martin 1 , Loi Do 1 , David Saloner 1 , Mark Wilson 1
1 Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States
MR imaging was used to 1) assess the changes in LV volumes, ejection fraction, LV mass, regional wall thickness, and 3D wall strain
as well as myocardial structure, edema, microvascular obstruction and intramyocardial haemorrhage in reperfused infarct in a single
imaging session, to ensure image co-registration and 2) compare LV changes over 10 weeks. MR imaging provides comprehensive
and serial characterization of evolved infarct. Myocardial edema, microvascular obstruction and hemorrhage are transient features of
reperfusion injury. Based on the MR pulse sequences used it appears five weeks is enough time to arrest fibrosis, but not LV dilation,
in reperfused infarct.
Myocardial Viability: Human Models
Hall B Monday 14:00-16:00 Computer 34
14:00 3648. Incremental Benefit of Cardiovascular MRI in the Evaluation of Patients with
Systemic Embolism
Monvadi B. Srichai 1 , Amelia M. Wnorowski 1 , Itzhak Kronzon 1 , Leon Axel 1 , Ambika
Nayar 1 , Gila Perk 1 , Allison G. Hays 2 , Mark Fisch 1 , Vivian S. Lee 1
1 NYU School of Medicine, New York, NY, United States; 2 Johns Hopkins, Baltimore, MD, United States
Echocardiography is often the sole imaging technique used for evaluation cardiac sources of embolism. However, studies have
demonstrated that up to 40% of patients with ischemic strokes often have no identifiable etiology. Contrast enhanced MRI with MRA
identified a cardiovascular source of embolism in an additional 20% of patient in this cohort that was undetected by echocardiography,
and hence provides a valuable adjunctive diagnostic imaging method for evaluation of patients with a potential cardiovascular source
of embolism, particularly in patients with a negative echocardiography study or who are unable to undergo transesophageal
echocardiography.
14:30 3649. Rapid Quantification of Systolic and Diastolic Transverse T1ρ Relaxation Times in
the Human Left Ventricle
Gerald A. Zsido II 1 , Julio Chirinos 2 , Larry Dougherty 3 , Kevin Koomalsingh 4 , James J.
Pilla 2,4 , Walter RT Witschey 1,4 , Hee Kwon Song 2 , Joseph H. Gorman III 4 , Robert C.
Gorman 4 , Ravinder Reddy 1
1 Radiology, University of Pennsylvania, Center for Magnetic Resonance and Optical Imaging, Philadelphia,
PA, United States; 2 University of Pennsylvania, Division of Cardiovascular Medicine, Philadelphia, PA, United
States; 3 Radiology, University of Pennsylvania, Philadelphia, PA, United States; 4 Surgery, University of
Pennsylvania, Philadelphia, PA, United States
A technique for rapid quantification of 1H relaxation times in the human myocardium during systole and diastole was developed. The
technique makes use of a T1ρ spin locking pulse cluster, followed by a short, multiecho, radial acquisition, from which k-spaceweighted
image contrast reconstruction is performed. An 8-fold acceleration of data acquisition was obtained in vivo, compared to a