ELECTRONIC POSTER - ismrm

14:30 4608. Improvement of Multislice Oxygen-Enhanced MRI of the Lung by Fully Automatic
Non-Rigid Image Registration.
Francesco Molinari 1,2 , Grzegorz Bauman 3 , Monika Eichinger 2 , Bernhard Geiger 4 ,
Lorenzo Bonomo 1 , Hans-Ulrich Kauczor 5 , Michael Puderbach 2
1 Department of Bioimaging and Radiological Sciences, Catholic University of Rome, Rome, Italy; 2 Department
of Radiology, German Cancer Research Center, Heidelberg, Germany; 3 Department of Medical Physics in
Radiology, German Cancer Research Center, Heidelberg, Germany; 4 Siemens Corporate Research, Princeton,
United States; 5 Department of Radiology, University of Heidelberg, Heidelberg, Germany
In oxygen-enhanced MRI, lung signal is measured repeatedly during different breathing cycles. Inconsistencies of respiratory phase
may hamper the quality of the parametric O2-maps. In this study, fully automatic non-rigid registration was assessed as a
postprocessing method to improve the quality of O2-MRI of the lung. This post-processing technique reduced spatial misalignment
among images and signal variability within the lung. O2-induced signal enhancement was not influenced by image registration.
Spatial heterogeneity of parametric O2-maps decreased significantly. As such, fully automatic non-rigid registration appears suitable
for improving the quality of multislice O2-MRI of the lung.
15:00 4609. Ultra-Short Echo Time (UTE) MR Imaging of the Lung: Assessment of Tissue
Density in the Lung Parenchyma
Masaya Takahashi 1 , Osamu Togao 1 , Riki Tsuji 1 , Ivan Dimitrov 1
1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United
States
The utility of ultra-short TE (UTE) imaging in conjunction with projection acquisition of the free induction decay helps to acquire the
MR signal from the lung parenchyma. We applied an UTE sequence for imaging of the murine lung at different positive endexpiratory
pressures (PEEP) in a 3 T clinical MRI system. The signal intensity and T2* of the lung parenchyma measured with a UTE
sequence reduced as the PEEP became higher where the lung volume increased. We found that both are highly correlated with the
lung volume.
Thursday 13:30-15:30 Computer 94
13:30 4610. Automated Airway Lumen Segmentation and Characterization for Use in Patients
with Traqueomalacya: A Feasibility Study
Piotr Alfred Wielopolski 1 , Pierluigi Ciet 2 , Gabriel Paul Krestin 1 , Martin H. Lequin 1 ,
Harm Tiddens 3 , Rashindra Manniesing 4
1 Radiology, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands; 2 Department of Medical-
Diagnostic Sciences and Therapies, Policlinico Universitario di Padova, Padova, Italy; 3 Department of
Pulmonology, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands; 4 Department of Informatics and
Radiology, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
The purpose of this work was to provide: first, a suitable acquisition scenario including static and dynamic 3D MRI sequences with
sufficient temporal and spatial resolution to provide good morphological information and visualization of dynamic events in the
central airways and, secondly, to provide the means for an automatic analysis program suitable to segment the airway lumen and a
dynamic evaluation of cross-sectional areas of the central airways down to the 2nd generation branching.
14:00 4611. MRI Assessment of Dynamic Lung Volume Changes in Subjects Using a Nasal
Expiratory Positive Airway Pressure (NEPAP) Device
Ding Xia 1 , Elan J. Grossman 1 , D M. Rapoport 2 , I Ayappa 2 , A V. Patel 2 , L Daugherty 3 ,
Jian Xu 1 , Kelly Anne Mcgorty 1 , Qun Chen 1
1 Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, United
States; 2 Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, United
States; 3 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States
The purpose of the current study is to use a real-time MRI technique for measuring lung volume changes caused by using a nasal
expiratory positive airway pressure (nEPAP) device, a new treatment for obstructive sleep apnea (OSA). This may help us better
understand the mechanism by which it treats OSA. Our results show there is an increase in functional reserve capacity (FRC) while
using the nEPAP device. Since end-expiratory hyperinflation is likely to produce increased traction in the trachea, this suggests the
main action of the nasal expiratory device may be to stiffen the upper airway through increased longitudinal traction.