ELECTRONIC POSTER - ismrm

Thursday 13:30-15:30 Computer 30
13:30 3596. Clinical Cardiac Imaging at 7 Tesla: A Validation Study.
Joseph J. Suttie 1 , Lance DelaBarre 2 , Greg J. Metzger 2 , Pierre Francois van de
Moortele 2 , Carl J. Snyder 2 , Peter Weale 3 , Stefan Neubauer 1 , Matthew D. Robson 1 , J
Thomas Vaughan 2
1 Department of Cardiovascular Medicine, University of Oxford, Oxford Centre for Clinical Magnetic
Resonance Research, Headington, Oxfordshire, United Kingdom; 2 University of Minnesota, Radiology Center
for Magnetic Resonance Research, Minneapolis, MN, United States; 3 Cardiovascular MR Research and
Development, Siemens Healthcare, Chicago, IL, United States
Clinical cardiac imaging at 7 T is attractive for spectroscopy, coronary and perfusion imaging. It offers improved signal and contrast
to noise, provided technical challenges of ECG and artifacts can be overcome. This study compares SSFP and FLASH imaging at
different field strengths: 1.5, 3 and 7 Tesla.
14:00 3597. Quantifying Right Ventricular Motion and Deformation Using 3D Cine DENSE
MRI
Daniel Alejandro Auger 1 , Xiaodong Zhong 2 , Ernesta Meintjes 1 , Fred Epstein 3 , Bruce
Spottiswoode 1,4
1 MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, Western Cape, South
Africa; 2 MR R&D Collaborations, Siemens Medical Solutions, Atlanta, GA, United States; 3 3Departments of
Radiology and Biomedical Engineering, University of Virginia, , Charlottesville VA, United States;
4 Radiology, University of Stellenbosch, Cape Town, South Africa.
Displacement encoding with stimulated echoes (DENSE) is a quantitative MRI technique used for measuring myocardial
displacement and strain at a high spatial resolution. Studies quantifying the motion of the right ventricle (RV) have been limited by the
RV’s thin wall, asymmetric geometry and complex motion. A free-breathing navigator gated spiral 3D cine DENSE sequence has
recently been developed, thus providing a well suited tool for capturing the complex behavior of the RV. This study involves
analyzing the RV’s 3D motion and strain at a previously unattainable spatial resolution. The results are consistent with previous
studies using myocardial tagging.
14:30 3598. Diffusion Tensor Imaging of Healthy and Cryo-Injured Pig Hearts
Patricia Dreessen de Gervai 1 , Victor Yang, Uta Sboto-Frankenstein, Valery Kupriyanov,
Lawrence Ryner
1 National Research Council Institute for Biodiagnostics, Winnipeg, Manitoba, Canada
Diffusion Tensor Magnetic Resonance Imaging (DTI) was used to assess myocardial architecture in healthy and in injured excised pig
hearts in which cryo-ablation was used to produce targeted infarctions. Using the lesion and penumbral region as seed points, fibers
were not detectable in the infarct region, FA was reduced and ADC values increased compared to healthy excised hearts. The
penumbral region contained traceable fibers although FA and ADC values were affected. This work suggests that the changes in fiber
architecture, FA and ADC involve not only the infarct area but also the adjacent tissue.
15:00 3599. Retrospective Self-Gated Free-Breathing Radial 3D Cine SSFP CMR Using Self-
Calibrated GRAPPA: A Feasibility Study
Noel C. Codella 1 , Pascal Spincemaille 2 , Jing Liu 2 , Martin Prince 2 , Yi Wang 2
1 Physiology, Cornell Weill Medical College, New York, NY, United States; 2 Radiology, Cornell Weill Medical
College
In this study, a 3D free-breathing self-calibrated radial GRAPPA cine-SSFP pulse sequence was developed to overcome the
limitations of 2D breath-hold imaging. Radial k-space sampling was employed to provide z-profile self-navigator to monitor
respiratory motion, and to allow for GRAPPA self-calibration.
Myocardial Function: Experimental & Human Studies III
Hall B Monday 14:00-16:00 Computer 31
14:00 3600. Quantification of 3D Cardiac Motion in Mice Using Multi-Phase DENSE MRI
Yong Chen 1,2 , Jia Zhong 1,2 , Xin Yu 1,2
1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States;
2 Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States
In the current study, we developed a multi-phase DENSE imaging method for quantification of 3D myocardial motion in mice. Only
five acquisitions were required to quantify both in-plane and longitudinal displacements on one slice. The results showed strong
agreement with 2D DENSE methods.