ELECTRONIC POSTER - ismrm

Tuesday 13:30-15:30 Computer 78
13:30 4346. A Diffusion Tensor Imaging Study of Longitudinal White Matter Degeneration in
Amyotrophic Lateral Sclerosis
Yu Zhang 1,2 , Norbert Schuff 1,2 , Susan C. Woolley 3 , Gloria Chiang 1,2 , Lauren Boreta 1,2 ,
Jonathan S. Katz 3 , Michael W. Weiner 1,2
1 CIND VA Medical Center, San Francisco, CA, United States; 2 UC San Francisco, San Francisco, CA, United
States; 3 Forbes Norris ALS Center, California Pacific Medical Center, San Francisco, CA, United States
We report longitudinal differences of white matter degradation in 16 amyotrophic lateral sclerosis (ALS) patients who were scanned at
7-month intervals, by using a preliminary longitudinal assessment of diffusion tensor MRI (DTI). Both tractography-guided ROI
analysis and voxel-wise whole brain analysis showed a significant decline of fractional anisotropy (FA) over time in the right
corticospinal tract (CST). Furthermore, the FA decline was significant in the localized (mild) subgroup of ALS but not the generalized
(severe) subgroup. These preliminary results suggest that longitudinal DTI measurements capture clinical progression of ALS.
14:00 4347. Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of
Subacute Sclerosing Panencephalitis
Richa Trivedi 1 , H Anuradha 2 , Atul Agarwal 2 , Ram KS Rathore 3 , Kashi N. Prasad 4 ,
Rajendra P. Tripathi 1 , Rakesh Kumar Gupta 5
1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2 Neurology,
Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3 Mathematics and Statistics,
Indian Institute of Technology, , Kanpur, Uttar Pradesh, India; 4 Microbiology, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 5 Radiodiagnosis, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Diffusion tensor tractography using FACT algorithm was performed on 20 children with different grades of subacute sclerosing
panencephalitis (SSPE) to look for probable correlation between tract-specific DTI metrics in major white matter pathways and
Jabbour classification based clinical grades. A significant inverse correlation was observed between fractional anisotropy (FA) in
major white matter tracts and clinical grades. We conclude that FA is a better measure than conventional MRI for the assessment of
clinical grade in these patients.
14:30 4348. Diffusion Tensor Imaging of Optic Neuritis and Its Recovery
Nourhan Zayed 1 , Fiona Costello 2 , Michael Smith 3,4 , Bradley Goodyear, 23
1 Electrical and Computer Engineering , University of Calgary, Calgary, Alberta, Canada; 2 Clinical
Neurosciences, University of Calgary, Calgary, Alberta, Canada; 3 Electrical and Computer Engineering,
University of Calgary, Calgary, Alberta, Canada; 4 Radiology, University of Calgary, Calgary, Alberta, Canada
Appropriate DTI measures to characterize the presence and severity of optic neuritis (ON) as well as its recovery are not established.
We hypothesized that the optic nerve experiencing ON may not actually exhibit significantly different FA or ADC from that of the
unaffected eye or over the course of recovery. Instead, we predicted that ON is characterized by a greater distribution of FA and ADC,
suggesting that acute ON is associated with more heterogeneous diffusion within the optic nerve. Variability of DTI measures, rather
than means, may be a more sensitive indicator of the presence of ON and its recovery.
15:00 4349. Effect of Central Nervous System Involvement in Systemic Lupus Erythematosus
Patients : Examination Using Diffusion Parameters and Volumetric Measurement
Shiou-Ping Lee 1 , Jie-Zhi Cheng 2 , Wen-Yang Chiang 3 , Chung-Ming Chen 2 , Kao-Lun
Wang 1
1 Department of Medical Imaging and Technology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2 Institute of
Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3 Center for Optoelectronic Biomedicine,
National Taiwan University Medical College, Taipei, Taiwan
None of systemic lupus erythematosus (SLE) studies examined diffusion tensor imaging (DTI) and volumetric measurement in the
same groups. This paper aimed to investigate the effect of central nervous system (CNS) involvement in SLE patients on two diffusion
parameters, i.e., fractional anisotropy (FA) and mean diffusivity (MD), and one volumetric measurement, i.e., volume. To accurately
define the corpus callosum boundaries, an automatic segmentation algorithm, cell-competition method, was adopted to delineate the
boundaries of the corpus callosum on mid-sagittal FA maps to calculate FA, MD and volume of corpus callosum.
Wednesday 13:30-15:30 Computer 78
13:30 4350. In Vivo Vascular Hallmarks of Diffuse Leukoaraiosis
Jinsoo Uh 1 , Uma Yezhuvath 1 , Yamei Cheng 1 , Hanzhang Lu 1
1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United
States
We characterized multiple domains of vascular changes in leukoaraiosis using in vivo MR techniques. Compared to NAWM, CBF in
leukoaraiosis regions was 38% lower (p=0.01) and CVR was 48% lower (p=0.005). Significant BBB leakage was also detected
(p=0.04). Quantitative analysis revealed that the extent of BBB leakage was positively correlated with apparent diffusion coefficient.
In addition, the total area of leukoaraiosis in the brain is correlated with the CVR in NAWM. This study shows that the vascular