ELECTRONIC POSTER - ismrm

15:00 4541. The Impact of Gd-DTPA on Breast 1 H MRS
Patrick John Bolan 1 , Eva H. Baker 2 , Lance Jay DelaBarre 1 , Hellmut Merkle 3 , Doug Yee 4 ,
Michael T. Nelson 5 , Lenore Everson 5 , Michael Garwood 1
1 Radiology/CMRR, University of Minnesota, Minneapolis, MN, United States; 2 Diagnostic Radiology
Department, NIH Clinical Center, Bethesda, MD, United States; 3 National Institute Neurological Disorders and
Stroke, NIH, Bethesda, MD, United States; 4 Masonic Cancer Center, University of Minnesota, Minneapolis,
MN, United States; 5 Radiology, University of Minnesota, Minneapolis, MN, United States
While 1 H MRS is increasingly being used in clinical studies of breast cancer, there has been some evidence that the use of
Gadolinium-based contrast agents prior to MRS can affect the spectra, broadening the choline resonance and reducing its area. This
work describes a study performing 1 H MRS at 4T before and after a bolus of Gd-DTPA. It was found that after the contrast injection
there was a small negative impact on both the choline and water peaks, with an effect size of 10-15%.
Wednesday 13:30-15:30 Computer 90
13:30 4542. Measurement of the Breast Density Using IDEAL-Dixon Imaging at 3T
Sungheon Kim 1 , Tess Clendenen 2 , Sherlin Lavianlivi 1 , Linda Moy 1 , Henry Rusinek 1 ,
Malcolm C. Pike 3 , Anne Zeleniuch-Jacquotte 4
1 Center for Biomedical Imaging, Radiology, NYU School of Medicine, New York, NY, United States;
2 Epidemiology, NYU School of Medicine, New York, NY, United States; 3 Preventive Medicine, USC Keck
School of Medicine, Los Angeles, CA, United States; 4 Environmental Medicine, NYU School of Medicine,
New York, NY, United States
This study was to assess if Dixon water/fat images could be used to monitor breast volume and density changes during the menstrual
cycle. Reproducibility of the volume and density measurement was assessed with data from four subjects. In addition, five healthy
premenopausal women were scanned once a week for four weeks. The median breast volume was smallest in the ovulatory phase and
largest in the late luteal phase. FG density was lowest at the follicular phase and highest in the late luteal phase. This result
demonstrates the feasibility of using Dixon imaging to monitor the change in the breast.
14:00 4543. Quantitative Evaluation of Fat Suppression Techniques for Breast MRI at 3.0T
Chen Lin 1 , Laurie Owens 1 , Hal Kipfer 1 , Helmuth Schultze-Haakh 2 , Brian Dale 2
1 Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN,
United States; 2 Siemens Healthcare, Marlven, PA
Quantitative assessment of the quality of fat suppression in breast MRI with four different techniques, conventional quick fat (QFS),
spectrally selective adiabatic inversion recovery (SPAIR), water only excitation (WE) and two point dixon (2PT DIXON) was made at
3.0T. The result demonstrates similar but inferior performance for QFS, SPAIR and WE. While 2PT DIXON is shown to provide
superior fat suppression, further development is needed.
14:30 4544. Determining the Sensitivity and Specificity of High Spatial Resolution 3.0T Breast
MRI in a High Risk Familial Breast Cancer Screening Cohort
Martin D. Pickles 1 , Lindsay W. Turnbull 1
1 Centre for MR Investigations, University of Hull, Hull, East Yorkshire, United Kingdom
Theoretically breast MR examinations at 3.0T should be superior to 1.5T studies. However, breast imaging on higher field strength
systems also pose problems such as larger chemical shift, susceptibility artefacts, B1 inhomogeneities and increased T1 relaxation
times. The aim of this work was to compare the sensitivity and specificity achieved by a 3.0T MR breast screening programme against
the published results of screening studies at 1.5T. In conclusion the diagnostic accuracy of MR breast screening at 3.0T does not seem
to be adversely effected by high field strength related artefacts and the results are comparable to those published at 1.5T.
15:00 4545. Assessing the Accuracy of a Commercial Computer Aided Diagnosis Package
(CADstream) in Determining the Level of Disease Post Neoadjuvant Chemotherapy in a
Cohort of Breast Cancer Patients
Martin D. Pickles 1 , Lindsay W. Turnbull 1
1 Centre for MR Investigations, University of Hull, Hull, East Yorkshire, United Kingdom
CADstream is a computer aided diagnosis package developed to aid in the interpretation of breast MR. Reports have demonstrated
that CADstream provides quicker interpretation, increased specificity and greater correlation with histological size. However, these
reports are based on the assessment of pre-treatment lesions and not post chemotherapy lesions where a treatment induced vascular
shutdown is anticipated. The aim of this study was to assess CADstream’s accuracy post chemotherapy. In conclusion this study
demonstrated by reducing the enhancement and difference thresholds the sensitivity can be increased resulting in fewer false negative
results.