ELECTRONIC POSTER - ismrm

Wednesday 13:30-15:30 Computer 105
13:30 4780. Relative Conspicuity of Prostate Cancer: Apparent Diffusion Coefficient Versus
Dynamic Contrast Enhancement
Daniel Jason Aaron Margolis 1 , Timothy McClure 1 , Steven Raman 1
1 Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United
States
Diffusion-weighted imaging (DWI) and dynamic contrast enhancement (DCE) can localize prostate cancer in situ, but it is unclear if
one is superior. DWI, Ktrans, Kep, Ve, and T2WI are compared with surgical pathology in 23 patients using a unitless variable, the
conspicuity ratio, the difference of the values from the ROI of the lesion and the contralateral side, divided by the average of these
values. Prostate cancer is more conspicuous on DWI ADC maps and on DCE than on T2WI, and more conspicuous on DCE than on
ADC, but Ktrans and Kep are not significantly different in terms of conspicuity.
14:00 4781. Intersequence Variability in Multiparametric-Derived 3D Prostate Tumor
Volumetrics at 3.0T
Fiona M. Fennessy 1 , Sota Oguro 1 , Yi Tang 1 , Robert V. Mulkern 1 , Steven Haker 1 , Ehud J.
Schmidt 1 , Sandeep Gupta 2 , Clare M. Tempany 1
1 Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2 GE Global Research, Niskayuna,,
NY, United States
Newer approaches for prostate cancer treatment mandate improvements in MR imaging to allow for accurate index lesion detection
and display, to guide biopsy and focal therapy. In 9 pathology-proven prostate cancer patients, we manually segmented tumor
according to multiparametric MR (mpMR) sequences using 3D-slicer software, and obtained volumetrics for each. Volumes based on
DCE maps were significantly greater than those based on ADC maps (p=0.011) or T2WI (p=0.001), possibly reflecting different
physiological properties of tumor assessed with mpMR. Volume discrepancies can be displayed in a single framework, and should be
taken into consideration for tumor mapping in focal therapy planning.
14:30 4782. The Utility of Prostate MRI Using Diffusion and Dynamic Enhanced Imaging in the
Evaluation of Patients Previously Biopsy Negative for Cancer
Andrew Dean Hardie 1
1 Radiology, Medical University of South Carolina, Charleston, SC, United States
Patients with an initial set of prostate biopsies which were negative for cancer were assessed by phased array MRI. All patients
subsequently had repeat prostate biopsy which was used as the gold standard. The diagnostic accuracy of MRI, negative predictive
value, and the difference in the number of biopsy samples performed in patients with cancer suspected by MRI and those unlikely to
have cancer by MRI were assessed. MRI was 100% sensitive, 91% specific, and had a 100% negative predictive value for cancer.
Less biopsy passes were performed in patients with an MRI read as likely to have cancer than those unlikely to have cancer by MRI.
15:00 4783. Multiparametric Prostate MR Imaging and Spectroscopy in Patients with High-
Risk Localized Prostate Cancer Before Radical Prostatectomy Assesses Risk of Extracapsular
Extension And/or Positive Margins.
Ernesto Castillo 1,2 , Emilio Hernandez 3 , Jose Maria Rodriguez-Barbero 4 , Pilar Perez
Sanz 1 , Javier Gonzalez 3 , Pedro Cabrera 3 , Javier C. Angulo, 23
1 Radiology, H.U. de Getafe, Getafe, Madrid, Spain; 2 Universidad Europea de Madrid; 3 Urology, H.U. de
Getafe; 4 Pathology, H.U. de Getafe
In 30 patients with high-risk localized (T1-2) prostate cancer the risk of extracapsular extension and affected margins before radical
prostatectomy were evaluated blindly before surgery. The pathologists’ evaluation of the biopsy cylinders predicted the risk
erroneously in 35% of the evaluations. Using multiparametric MRI and MR spectroscopic imaging, diffusion-weighted imaging and
dynamic CE-MRI with an endorectal coil the radiologist did so in 18.3%. Multiparametric MRI of the prostate preoperatively alerts
upon the risk of extracapsular disease in high-risk localized prostate cancer better than accurate review of transrectal biopsy.
Thursday 13:30-15:30 Computer 105
13:30 4784. MR-US Fusion for Targeted Prostate Biopsy
Clifford Weiss 1 , Michael Seitz 2 , Karin Herrmann 3 , Arno Graser 3 , Berthold Kiefer 4 ,
Martin Requardt 4 , Jens Fehre 4 , Ralf Nanke 4 , Mamadou Diallo 5 , Parmeshwar Khurd 5 , Ali
Kamen 5 , Wolfgang Wein 5
1 Center Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United
States; 2 Urology Department, Ludwig Maximilian Universität München, München, Germany; 3 Radiology
Department, Ludwig Maximilian Universität München, München, Germany; 4 Siemens Healthcare, Erlangen,
Germany; 5 Imaging & Visualization Department, Siemens Corporate Research, Princeton, NJ, United States
We aim to improve prostate targeted biopsy procedures, by taking pre-acquired diagnostic MRI images, and actively fusing them to
the real-time trans-rectal ultrasound. In this way the diagnostic power of prostate MRI is married to the flexible, rapid and inexpensive
ultrasound guided procedure. We propose a system based on a magnetically tracked freehand ultrasound probe, combined with a novel
powerful deformable registration workflow that effectively compensates prostate organ deformation between the two modalities. We