ELECTRONIC POSTER - ismrm

14:30 4240. DCE-MRI and DW-MRI in Characterization of Spinal Metastasis
David H. Gultekin 1,2 , Hebert A. Vargas Alvarez 3 , Cecilia Wassberg 4 , Jason A. Koutcher 1 ,
Yoshiya Yamada 5 , Eric Lis 2 , Sasan Karimi 2 , Lawrence H. Schwartz 2
1 Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, United States; 2 Radiology, Memorial
Sloan-Kettering Cancer Center, New York, United States; 3 Radiology, Sloan-Kettering Institute, New York,
United States; 4 Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer C, New York, United States;
5 Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, United States
The combination of DCE-MRI and DW-MRI in the assessment of metastatic cancer of various primaries (breast, prostate, melanoma,
colorectal, papillary thyroid, RCC and NSCLC) in the spine has been evaluated for treatment response monitoring in patients
undergoing radiotherapy.
15:00 4241. Fast Spin-Echo Triple Echo Dixon: Initial Clinical Experience with a Novel Pulse
Sequence for Simultaneous Fat Suppressed and Non Fat Suppressed T2-Weighted Spine Mr
Imaging
Russell Norman Low 1,2 , Matthew J. Austin 3 , Jingfei Ma 4
1 Sharp and Children's MRI Center, San Diego, CA, United States; 2 San Diego Imaging, San Diego, CA, United
States; 3 Radiology, Univeristy of California at San Diego, San Diego, CA, United States; 4 Department of
Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
We evaluate a novel Dixon based FSE sequence (fTED) for spine imaging that efficiently provides T2 weighted imaging with and
without fat suppression in a single acquisition. Compared to STIR images the fTED water images showed equal homogeneity of fat
suppression with less motion artifact, sharper anatomic detail, and less susceptibility artifact. The T2 fTED images without fat
suppression were equivalent to T2 FRFSE images for lesion detection. FTED provides T2 imaging of the spine with and without fat
suppression with a 56% savings in scan time compared to STIR and T2 FRFSE imaging.
Advanced Imaging of Dementia & Neurodegenerative Disease, Part I
Hall B Monday 14:00-16:00 Computer 72
14:00 4242. BOLD Signal Fractal Dimension Mapping in AD Demonstrates Increase
Microvascular Activity and Metabolism When Combined with Spectroscopy
Mohammed Warsi 1 , D William Molloy 2 , Tim Standish 2 , Graeme Wardlaw 3 , Michael D.
Noseworthy 4
1 School of Biomedical Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; 2 Medicine,
St. Peters Hospital, Hamilton, Ontario, Canada; 3 Medical Physics and Applied Radiation Sciences, McMaster
University, Hamilton, Ontario, Canada; 4 Electrical and Computer Engineering, School of Biomedical
Engineering, McMaster University, Hamilton, Ontario, Canada
We present a BOLD signal fractal dimension (FD) mapping approach to assess the tissue microvascular environment in Alzheimer's
dementia. The periodicity or temporal complexity can be quantified using this method thus allow insight into the underlying
microvascular processes. Alzheimer’s Disease (AD) is associated with regional hypermicrovascularity, especially in the deep grey
matter. Furthermore our BOLD FD was inversely correlated to our MRS measures of total creatine.
14:30 4243. Automatic Segmentation of Hippocampal Subfields in T2-Weighted in Vivo MRI
Hongzhi Wang 1 , John B. Pluta 2 , Brian B. Avants 1 , Sandhitsu R. Das 1 , Caryne Craige 1 ,
Murat Altinay 1 , Michael W. Weiner 3 , Susanne Mueller 3 , Paul A. Yushkevich 1
1 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 Department of
Neurology, University of Pennsylvania, Philadelphia, PA, United States; 3 Center for Imaging of
Neurodegenerative Diseases, VA Medical Center, San Francisco, CA, United States
To be added
15:00 4244. A Diffusion Tensor Imaging Study of Cross-Sectional and Longitudinal White
Matter Alterations in Frontotemporal Lobar Degeneration
Yu Zhang 1,2 , Maria Carmela Tartaglia 2 , Norbert Schuff 1,2 , Gloria Chiang 1,2 , Christopher
Ching 1,2 , Howard J. Rosen 2 , Bruce L. Miller 2 , Michael W. Weiner 1,2
1 CIND VA Medical Center, San Francisco, CA, United States; 2 UC San Francisco, San Francisco, CA, United
States
Behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive nonfluent aphasia (PNFA) are three
major clinical subtypes of frontotemporal lobar degeneration (FTLD). In this study, cross-sectional and a preliminary longitudinal
diffusion tensor imaging (DTI) analyses were performed in 12 bvFTD, 6 SD, 6 PNFA, and 19 healthy control (CN) subjects. Crosssectional
analysis revealed bvFTD is associated with a characteristic pattern of fractional anisotropy (FA) reductions in the frontal and
temporal regions, SD predominantly affects the uncinate fasciculus, and PNFA affects the left arcuate fasciculus. Preliminary
longitudinal analysis suggests that DTI captures disease progression in FTLD.