ELECTRONIC POSTER - ismrm

improvements in motor deficit over the same time period. ASL CBF images from each patient are also compared with age-matched
stroke-free controls via a one-to-many statistical analysis.
14:00 4411. Recovery Pattern in Chronic Stroke Post-Physiotherapy : An FMRI Study
Ashu Bhasin 1 , Senthil S. Kumaran 2 , M.V. Padma 1 , Sujata Mohanty 3 , Rohit Bhatia 1
1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India; 2 DEPARTMENT OF
N.M.R., ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, DELHI, India; 3 Stem Cell
Facility, All India Institute of Medical Sciences, New Delhi, India
Synopsis: Physiotherapy based on mirror therapy concept was administered to stroke patients for 8 weeks. BOLD mapping was
carried out for fist-clenching tasks of paretic hand. It has been observed that during observation of a movement, motor areas in the
primary and premotor cortex show enhanced activation when a subject observes the unaffected hand in a mirror or in simulated
environments.
14:30 4412. Voxel Based Lesion Symptom Mapping for the Identification of Critical Regions for
Motor Recovery After Stroke
Peter Chang 1 , Xue Wang 1 , Darren Gitelman 1,2 , Ryan Lo 1 , Robert Levy 1,3 , Justin
Hulvershorn 4 , Todd Parrish 1
1 Radiology, Northwestern University, Chicago, IL, United States; 2 Neurology, Northwestern University;
3 Neurological Surgery, Northwestern University; 4 Northstar Neuroscience, Seattle, Wa
VLSM was conducted on 151 chronic stroke subjects from 26 imaging centers with different MR vendors and field strengths. The
results identify regions in the corona radiata that appear to assimilate motor, pre-motor and sensory information similarly for right and
left hemisphere lesions. There were significant results for dominant lesions but not non-dominant lesions. This indicates that following
stroke of the non-dominant hemisphere, reorganization of the dominant hemisphere occurs to a greater degree than the reorganization
of the non-dominant hemisphere following a dominant lesion. This population based study may improve the ability to give an accurate
prognosis and optimize treatment.
15:00 4413. Autologous Intravenous Stem Cells Infusion in Chronic Stroke : A Pilot Study in
Indian Patients
Ashu Bhasin 1 , Senthil S. Kumaran 2 , M.V. Padma 1 , Sujata Mohanty 3 , Rohit Bhatia 1
1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India; 2 Department of N.M.R.,
All India Institute of Medical Sciences, New Delhi, Delhi, India; 3 Stem Cell Facility, All India Institute of
Medical Sciences, New Delhi, India
Autologous mesenchymal stem cells were infused intravenously in chronic stroke patients with a dose of 5 x 10 8 cells through median
cubital vein in 4-6 hours. The experimental group was treated with stem cells and a focused physiotherapy regime and the control
group with only physiotherapy regime. It was observed that stem cell transplantation leads to therapeutic benefits as measured on
clinical (fugel meyer & barthel index ) and functional markers (BOLD, DTI) augmenting neural plasticity.
Wednesday 13:30-15:30 Computer 82
13:30 4414. Where Is the “clinical Relevant” Penumbra? a Voxel-Based Analysis in Acute
Stroke Patients
Charlotte Rosso 1,2 , Yohan Attal 2 , Sophie Crozier 1 , Romain Valabrègue 3 , Dider Dormont,
2,4 , Sylvain Baillet 2 , Stephane Lehericy 3,5 , Yves Samson 1
1 Urgences Cerebro-Vasculaires, Pitie-Salpetriere Hospital, Paris, France; 2 CRICM, INSERM UMR S_975,
CNRS UMR_7225, Equipe COGIMAGE, Pitie-Salpetriere Hospital, Paris, France; 3 Centre for NeuroImaging
Research – CENIR, Pitie-Salpetrière Hospital, Paris, France; 4 Neuroradiology Department, Pitie-Salpetriere
Hospital, Paris, France; 5 Neuroradiology Department, Pitie-Salpetriere, Paris, France
In this study, we used, in 43 MCA acute stroke patients with initial and follow-up MRI, ADC maps to study the tissue-at-risk location.
To investigate this issue, time course of ADC changes between initial and follow-up MRI, impact of recanalization in final ADCdefined
infarct areas, and relationship with key regions associated with poor outcome were assessed. Infarct expansion concerns
perisylvian regions but also the deep MCA territory and part of the CST. The comparison of ADC maps of recanalized vs. nonrecanalized
and good vs. poor outcome patients shows a great overlap and involved the lenticular nucleus and the CST.
14:00 4415. Acute Change of Tissue Perfusion in Acute Stroke Patients After TPA Treatment
Hongyu An 1 , Andria Ford 2 , Cihat Eldeniz 1 , Katie Vo 2 , Rosana Ponisio 2 , Yasheng Chen 1 ,
William Powers 1 , Jin-Moo Lee 2 , Weili Lin 1
1 University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; 2 Washington University in St.
Louis, St. Louis, MO, United States
Spatial heterogeneity of tissue perfusion change was detected in acute patients after tPA treatment. Concurrent development of
reperfusion and new hypoperfusion were observed. Compared to the reperfused region, the nonreperfused region had a significantly
greater MTT prolongation, suggesting that tissue with a more severe initial injury is more likely to remain hypoperfused. Moreover,
the nonreperfused regions had the highest risk of infarction, followed by new hypoperfused and reperfused regions.