ELECTRONIC POSTER - ismrm

15:00 4149. 3D Reduced-FOV MR Thermometry with Fat Suppression Using a Hybrid Method
Combining a 2DRF Pulse, Parallel Imaging, and UNFOLD
Chang-Sheng Mei 1,2 , Jing Yuan 3 , Lawrence P. Panych 4 , Bruno Madore 4 , Nathan J.
McDannold 4
1 Department of Physics, Boston College, Chesnut Hill, MA, United States; 2 Department of Radiology, Brigham
and Women's Hospital,, Harvard Medical School, Boston, MA, United States; 3 Department of Diagnostic
Radiology and Organ Imaging, Chinese University of Hong Kong, Shatin, Hong Kong; 4 Department of
Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
3D MR thermometry using PRF shift has issues due to the requirement of relatively long TE and the presence of fat. A hybrid method
combining 2DRF pulse, parallel imaging, and UNFOLD in a 3D sequence is proposed here, which offers advantages in terms of
spatial coverage and measurement accuracy, as compared to typically-used 2D sequences.
Cardiovascular Interventional & Devices
Hall B Monday 14:00-16:00 Computer 66
14:00 4150. Mr Guided Transmyocardial Delivery of Hepatocyte Growth Factor Gene Into
Infarct Scar with Established Remodelled Left Ventricle
Maythem Saeed 1 , David Saloner 1 , Phillip Ursell 2 , Loi Do 1 , Mark Wilson 1 , Alastair J.
Martin 1
1 Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States;
2 Pathology, University of California San Francisco, San Francisco, Ca, United States
It is unknown whether MR-guided transendocardial delivery of hepatocyte growth factor gene (HGF) is effective in ameliorating LV
remodelling. XMR suite (x-ray cath-lab and a 1.5T MR scanner) for real-time imaging, transendocardial delivery and assessing the
gene effects in swine with remodelled LV. Six MR sequences were used for evaluation of the efficacy of therapy. MR-guided
transendocardial delivery of HGF a) ameliorated global function and 3D strain, b) activated perfusion, neovascularization and
myogenesis in scar and c) reduced infarct. The combination of this therapy and XMR technique may be useful in patients with
ischemic myocardium and cell loss (apoptosis).
14:30 4151. Visualization of Ablation Lesions by Dynamic Contrast Enhanced MRI
Andriy Shmatukha 1 , Bharathi Sundaram 2 , Xiuling Qi 2 , Samuel Oduneye 2 , Jeff A.
Stainsby 1 , Graham A. Wright 2 , Eugene Crystal 2
1 Applied Science Laboratory, GE Healthcare, Toronto, Ontario, Canada; 2 Sunnybrook Health Sciences Centre,
Canada
An approach for rapid and reliable visualization of radiofrequency (RF) ablation lesions using dynamic contrast enhanced MRI is
presented. Novel processing algorithms are presented that demonstrate the ability to identify distinct regions within RF lesions and can
do so more rapidly than traditional dynamic contrast enhanced processing methods.
15:00 4152. An Approach for MRI Based Pre-Operative Planning of Cardiac Interventions Via
Trans-Apical Access
Erol Yeniaras 1 , Nikhil Navkar 1 , Zhigang Deng 1 , Mushabbar A. Syed 2 , Nikolaos V.
Tsekos 1
1 Computer Science, University fo Houston, Houston, TX, United States; 2 Division of Cardiovascular Medicine,
University of Kentucky, United States
The aim of this work is to implement an approach for pre-operative planning of cardiac interventions via a trans-apical access using
CINE cardiac images. Multislice sets of short and long axis planes were analyzed to identify access corridors in 3D, from the apex to
the base of the heart, which ensure that a tool may transverse the ventricle without contact to the epicardial wall for all heart phases.
Studies illustrate that apical areas can be delineated through which a tool may be inserted to access the mitral valve along a straight
path and the aortic valve through a curved one.
15:30 4153. MR-Guided Electrophysiology System for Activation and Pace Mapping in Left
Ventricle
Samuel O. Oduneye 1 , Andriy Shmatukha 2 , Vladimir Verpakhovski 3 , Charles L.
Dumoulin 4 , Ehud Schmidt 5 , Eugene Crystal 6 , Graham A. Wright 1
1 Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada;
2 GE Healthcare, Toronto, Ontario, Canada; 3 Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;
4 GE Global Research Center, Niskayuna, NY, United States; 5 Brigham and Women's Hospital & Massachusetts
General Hospital, Boston, MA, United States; 6 Arrhythmia Services, Sunnybrook Health Sciences Centre,
Toronto, Canada
In recent studies, electrophysiology information has been compared with pre-acquired MR images to determine the relation between
the two measurements; however, that approach is sensitive to registration errors and changes in anatomical conditions. Here, we
present an MR-compatible EP system for real-time MR imaging able to directly locate and characterize electrical properties of
potential arrhythmogenic regions in the left ventricle (LV) by measuring local conduction velocities at different pacing frequencies.