ELECTRONIC POSTER - ismrm

14:30 4599. Producing Hyperpolarized Gases Via Dynamic Nuclear Polarization and
Sublimation
Arnaud Comment 1,2 , Sami Jannin 3 , Jean-Noël Hyacinthe 4 , Pascal Miéville 3 , Riddhiman
Sarkar 3 , Puneet Ahuja 3 , Paul Romeo Vasos 3 , Xavier Montet 4 , François Lazeyras 4 , Jean-
Paul Vallée 4 , Joseph A. Konter 5 , Patrick Hautle 5 , Ben van den Brandt 5 , Jean-Philippe
Ansermet 2 , Rolf Gruetter 1,6 , Geoffrey Bodenhausen 3,7
1 Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne,
Switzerland; 2 Institute of Condensed Matter Physics, Ecole Polytechnique Fédérale de Lausanne, Lausanne,
Switzerland; 3 Laboratory of Biomolecular Magnetic Resonance, Ecole Polytechnique Fédérale de Lausanne,
Lausanne, Switzerland; 4 Department of Radiology, Université de Genève, Genève, Switzerland; 5 Paul Scherrer
Institute, Villigen, Switzerland; 6 Departments of Radiology, Universités de Lausanne et Genève, Lausanne and
Genève, Switzerland; 7 Department of Chemistry, Ecole Normale Supérieure, Paris, France
A method to produce hyperpolarized gases by dynamic nuclear polarization and subsequent sublimation was designed. The method
was illustrated by applications to 129 Xe in xenon gas, leading to the enhancement of the nuclear magnetic resonance signal-to-noise by
four orders of magnitude. The main advantage of this new hyperpolarization method lies in its ability to produce highly polarized
gases with large throughputs, on the order of tens of several liters per hour.
15:00 4600. A Dedicated Coil Configuration for Hyperpolarized 129Xe Imaging at 1.5 T
Armin Purea 1 , Kevin Teh 2 , Michael Barlow 2 , Dominik Berthel 1 , Alexander Weisser 1 , Ian
Hall 3 , Peter Morris 2
1 Rapid Biomedical GmbH, Rimpar, Germany; 2 Sir Peter Mansfield Magnetic Resonance Centre, University of
Nottingham, Nottingham, United Kingdom; 3 IPSET, University of Nottingham, Nottingham, United Kingdom
Presented are preliminary results from a novel coil configuration for 129Xe lung imaging. A non-circular birdcage was used as a
transmit coil and a 8 channel receive coil were proposed. The coils were designed to utilise the bore space as much as possible to
enhance patient comfort whilst not compromising the image quality. Initial images obtained using a SPGR sequence shows great
promise. Scan time for lung patients will potentially decrease with the use of parallel receivers which were designed for optimum
signal as much as flexibility.
15:30 4601. 3D Hyperpolarized 3He Imaging of Human Lung with Isotropic Spatial Resolution
Using 3D-Cones
Jian-Xiong Wang 1 , Alexei V. Ouriadov 2 , Jeffrey A. Stainsby 3 , Grace E. Parraga 2 , Giles
Santyr 2,4
1 Applied Science Laboratory, GE HEALTHCARE, London, ON, Canada; 2 Robarts Research Institute, The
University of Western Ontario, London, ON, Canada; 3 Applied Science Laboratory, GE HEALTHCARE,
Toronto, ON, Canada; 4 Dept. of Medical Biophysics, The University of Western Ontario, London, ON, Canada
A true 3D isotropic spatial resolution imaging method for Hyperpolarized He-3 human lung imaging using 3D-cones sequence is
presented. The isotropic voxel size improves accuracy for co-registration, lung volume measurement and analysis for abnormalities in
the lung.
Tuesday 13:30-15:30 Computer 94
13:30 4602. Evaluation of Global Surface-To-Volume Ratio of Rabbit Lung Using
Hyperpolarized 129Xe Uptake Spectroscopy at 1.5T
Yulin Chang 1 , Jaime F. Mata 1 , Talissa Altes 1 , John P. Mugler III 1 , Kai Ruppert 1
1 Radiology, University of Virginia, Charlottesville, VA, United States
Hyperpolarized xenon-129 dissolves into lung tissue and binds hemoglobin and the dissolved-phase (DP) xenon molecules exchange
with the gas-phase molecules via diffusion. Therefore the initial rate of the signal replenishment of the DP xenon following a
saturation is proportional to both square root of time and lung surface area. In this work we demonstrate the possibility of measuring
lung surface-to-volume ratio using DP xenon signals at short delays after a complete saturation in a rabbit model.
14:00 4603. Long-Range Diffusion of Hyperpolarized 3He in Normal and Emphysematous Rat
Lungs
Ignacio Rodriguez 1,2 , Laura Carrero-Gonzalez, 1,3 , Thomas Kaulisch 3 , Detlef Stiller 3 ,
Jose Manuel Perez-Sanchez 4 , Jesus Ruiz-Cabello 1,2
1 Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain; 2 CIBER de Enfermedades
Respiratorias, Madrid, Spain; 3 Boehringer Ingelheim Pharma, Biberach an der Riss, Germany; 4 Univ. Paris-Sud,
CNRS, Orsay, France
Using long-range diffusion MRI, ADC of rats with induced emphysema in one lobe has been performed. The results show a
statistically significant increase of ADC in the emphysematous lobe at breath-hold, whereas no significant difference is seen at end
expiration. Collateral ventilation could play a role in these results. The increase seen at breath-hold agrees with the results found by
other workers.