ELECTRONIC POSTER - ismrm

15:30 3731. Fast Plaque Burden Assessment of the Femoral Artery Using 3D Black-Blood MRI
and Automated Segmentation
Bernard Chiu 1 , Xihai Zhao 1 , Jinnan Wang 2 , Niranjan Balu 1 , Chun Yuan 1 , William S.
Kerwin 1
1 Radiology, University of Washington, Seattle, WA, United States; 2 Clinical Sites Research Program, Philips
Research North America, Briarcliff Manor, NY, United States
Peripheral arterial disease (PAD) is a serious health issue in the western world. Recent advances in high-resolution MRI have allowed
noninvasive and detailed assessment of PAD, including black-blood MRI visualization of the vessel wall. Because the length of a
femoral artery is substantial, a long field of view is required to image the femoral artery. Manual outlining of wall boundaries along
the entire length of the femoral artery is an arduous task. In this work, we proposed and demonstrated an automatic algorithm that is
capable of accurately segmenting the lumen and wall boundaries along the majority of the femoral artery.
Tuesday 13:30-15:30 Computer 39
13:30 3732. Hemorrhage Delineation and Blood Suppression Evaluation in Slab-Selection
Phase-Sensitive Inversion-Recovery (SPI) Sequence with MRI
Dongxiang Xu 1 , Jinnan Wang 2 , Williams Kerwin 1 , Chun Yuan 1
1 Radiology, University of Washington, Seattle, WA, United States; 2 Philips Research North America,
Jinnan.Wang@philips.com, Seattle, WA, United States
Intraplaque hemorrhage (IPH) into the carotid atherosclerotic plaque has shown significant association with clinical symptoms and is
believed to be a major factor causing plaque instability and progression according to previous histopathological and prospective
studies. With the development of magnetic resonance imaging (MRI) in clinical diagnostics, several techniques have been developed
to enable and improve the IPH evaluation. However, automated hemorrhage detection has been challenging due to either low IPH
contrast or poor lumen contrast. Purpose: In this study, by incorporating the improved IPH and lumen contrasts in Slab-selection
Phase-sensitive Inversion-recovery (SPI) MRI sequence, we develop a novel and robust image segmentation approach to
automatically locate and delineate IPH in MR data. Quantitative IPH and lumen analysis results by this automatic segmentation
technique were compared to a human reader, which demonstrated highly consistent performance.
14:00 3733. Direct and Indirect Surface Coil Correction for Cardiac Perfusion MRI
Hui Xue 1 , Sven Zuehlsdorff 2 , Jens Guehring 1
1 Corporate Research, Siemens Corporation, Princeton, NJ, United States; 2 CMR Research and Development,
Siemens Healthcare, Chicago, IL, United States
Although the first-pass myocardial perfusion MRI has proven its effectiveness in the early diagnosis of suspected ischemic heart
diseases, this technique is still not routinely used. Certain technical difficulties prevent perfusion MRI from being added into the
clinical workflow. Among of them includes the B1-field inhomogeneity caused by non-uniform characteristics of the receiver coils
which still lacks intensive studies, when compared to perfusion imaging sequences or motion compensation. We therefore propose
algorithms to perform the surface coil inhomogeneity correction (SCC) using proton density (PD) weighted images and B-Spline Free-
Form Deformation (FFD).
14:30 3734. Saturation Correction of Dynamic Contrast Enhanced MRI Uptake Curves for
Quantitative Myocardial Blood Flow Measurements Using an Assumed T 1 for Blood
John David Biglands 1 , Abdulghani Larghat 1 , Sven Plein 1 , David L. Buckley 1 , Michael
Jerosch-Herold 2 , Derek Magee 3 , Roger Boyle 3 , Aleksandra Radjenovic 1
1 School of Medicine, University of Leeds, Leeds, UK, United Kingdom; 2 Radiology, Brigham and Womens
Hospital, Boston, MA, United States; 3 School of Computing, University of Leeds, Leeds, United Kingdom
Dynamic contrast enhanced magnetic resonance imaging of the myocardium using sufficiently high doses to be clinically useful
generates uptake curves that require correction for signal saturation effects before they can be used for myocardial blood flow (MBF)
estimation. Such corrections require knowledge of the native T1 of the blood and myocardium. This abstract shows that using an
assumed blood T1 enables saturation correction of typical clinical datasets without the need for time consuming T1 measurements.
MBF estimates from nine patients were consistent with literature values and were shown to be robust to variations in the assumed T1
of blood.
15:00 3735. Novel MRI T2 Mapping for Improved Myocardial Tissue Characterisation
Taigang He 1 , Sanjay Prasad 1 , Guang-Zhong Yang 1 , Dudley Pennell 1 , David Firmin 1
1 Royal Brompton Hospital and Imperial College London, London, United Kingdom
Synopsis: The aim of this study was to develop a novel T2 mapping method for improved myocardial tissue characterisation. The
developed T2 sequence resulted in improved resolution with shorter echo time and echo spacing. The novel technique was
consequently evaluated on nine human subjects. Preliminary results demonstrated that all images acquired were of good quality. Pixel
wise T2 curve is well fitted and T2 mapping in the whole myocardium appeared homogeneous. This study suggests that T2 mapping
may potentially be used for assessing regional disease variations across the myocardium.