ELECTRONIC POSTER - ismrm

Hall B Monday 14:00-16:00 Computer 8
14:00 3276. Improved Temporal Resolution for Hyperpolarized 13 C 3D Dynamic MRSI with
Compressed Sensing
Peder E. Z. Larson 1 , Simon Hu 1 , Michael Lustig 2 , Adam B. Kerr 2 , Sarah J. Nelson 1 , John
Kurhanewicz 1 , John M. Pauly 2 , Daniel B. Vigneron 1
1 Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United
States; 2 Electrical Engineering, Stanford University, Stanford, CA, United States
In this project, we developed improved sampling and reconstruction strategies to provide finer temporal resolution for hyperpolarized
carbon-13 3D time-resolved MRSI with compressed sensing and multiband excitation pulses. These improved compressed sensing
strategies better exploit the temporal redundancy. Results are shown with a 32-fold acceleration for a 2 sec temporal resolution, 3D
dynamic MRSI acquisition.
14:30 3277. Time Resolved Metabolic 13C MRS Using Hyperpolarised [1-13C]pyruvate in a
Transgenic Mammary Cancer Model
Sadia Asghar Butt 1 , Lise Vejby Søgaard 1 , Mette Hauge Lauritzen 1 , Jan Henrik
Ardenkjær-Larsen 2 , Lars H. Engelholm 3 , Susanne Holck 4 , Peter Magnusson 1 , Per
Åkeson 1
1 Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark; 2 GE
Healthcare, Hillerød, Denmark; 3 Bartholin Institute, Copenhagen Biocenter; 4 Department of pathology,
Copenhagen University Hospital Hvidovre
There is a need for monitoring of disease progression and treatment response in breast cancer using metabolic biomarkers. We have
applied the technique of time resolved hyperpolarised 13C metabolic MRS to the transgenic mammary cancer mouse model, MMTV-
PymT. We use measurements of the lactate dehydrogenase (LDH) rate constant reflecting the conversion of hyperpolarized [1-
13C]pyruvate to [1-13C]lactate in vivo to extract information about the metabolic the status of the tissue Our initial results show that
we are able to monitor the changes in LDH kinetics during tumour development and indicate that the enzyme activity correlate to
disease progression.
15:00 3278. In Vivo Detection of Rat Brain Metabolism Using Hyperpolarized Acetate
Mor Mishkovsky 1,2 , Arnaud Comment 1,2 , Rolf Gruetter 1,3
1 Laboratory for Functional and Metabolic Imaging , Ecole Polytechnique Fédérale de Lausanne, Lausanne,
Switzerland; 2 Department of Radiology, Université de Lausanne, Lausanne, Switzerland; 3 Departments of
Radiology, Universités de Lausanne et Genève, Lausanne and Genève, Switzerland
In vivo localized 13 C MRS of a rat brain was performed in a 9.4T animal scanner after infusion of a hyperpolarized 1- 13 C and 13 C 2
sodium acetate solution. It is demonstrated that hyperpolarized 13 C-labeled acetate rapidly enters the brain and its metabolism can be
detected within the time window defined by the lifetime of the carboxyl carbon hyperpolarized spin state. We present a new sequence
designed to transfer the carboxyl nuclear polarization onto the methyl carbon spin of 13 C 2 acetate in order to assign the metabolic
peaks observed in vivo.
15:30 3279. Toward Microtesla MRI of Hyperpolarized Carbon-13 for Real-Time Metabolic
Imaging
Vadim S. Zotev 1 , Tuba Owens 1 , Igor M. Savukov 1 , Andrei N. Matlashov 1 , John J. Gomez 1 ,
Michelle A. Espy 1
1 Applied Modern Physics Group, Los Alamos National Laboratory, Los Alamos, NM, United States
Hyperpolarization of C-13 has enabled real-time metabolic imaging of C-13 labeled substances with unprecedented signal-to-noise
levels. Because hyperpolarization is performed outside an MRI scanner, high magnetic fields of conventional MRI offer little
advantage in terms of C-13 polarization. We propose an ultimate low-field MRI scanner for imaging hyperpolarized C-13. It uses only
microtesla-range magnetic fields and employs SQUID sensors to measure MRI signals. We present the first images acquired by
SQUID-based microtesla MRI with dynamic nuclear polarization. We also report the first NMR spectra of C-13 at microtesla fields.
Our results demonstrate feasibility and potential of the proposed imaging approach.
Tuesday 13:30-15:30 Computer 8
13:30 3280. A Bayesian Approach to Modeling the Delivery of a Hyperpolarized Substrate
Matthew E. Merritt 1,2 , Crystal Harrison 3 , A Dean Sherry 4,5 , Craig R. Malloy 4,6 , G Larry
Bretthorst 7
1 Advance Imaging Research Center, UT Southwestern Med. Center, Dallas, TX, United States; 2 Radiology,
UTSW Medical Center, Dallas, TX, United States; 3 Physics, University of Texas at Dallas, Richardson, TX,
United States; 4 AIRC, UTSW Medical Center, Dallas, TX, United States; 5 Chemistry, University of Texas at
Dallas, Richardson, TX, United States; 6 Cardiology, North Texas VA Hospital, Dallas, TX, United States;
7 Radiology, Washington University in St. Louis, St. Louis, MO, United Kingdom
A primary challenge to extracting quantitative metabolic fluxes from metabolism of a hyperpolarized substrate is modeling the
delivery of the molecular imaging agent itself. Here, a tracer is co-infused with [1- 13 C] pyruvate. A model of the delivery and decay of