ELECTRONIC POSTER - ismrm

14:30 4679. Blood Oxygen-Level Dependent (BOLD) MR Imaging of Diabetic Nephropathy-
Preliminary Study
Zhen Jane Wang 1 , Rahi Kumar 1 , Benjamin M. Yeh 1 , Suchandrima Banerjee 2 , Chi-yuan
Hsu 3
1 Department of Radiology and Biomedical Engineering, University of California, San Francisco, San Francisco,
CA, United States; 2 Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States;
3 Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA,
United States
The preliminary data showed decreased medullary R2* values (corresponding to increased oxygen bioavailability) in patients with
diabetic kidney disease compared to healthy volunteers; and the decrease in medullary R2* values appeared to be related to the degree
of kidney disease.
15:00 4680. Free Breathing Renal BOLD Signal Frequency Assessment Following Diuresis
Brendan Boyd 1 , Michael D. Noseworthy 2
1 School of Biomedical Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; 2 Electrical
and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario,
Canada
Real time, free breathing, T2*-weighted (BOLD) images of the kidneys were retrospectively motion corrected and analyzed for
physiologic spectral energies. Following induced diuresis a corresponding decrease in cardiac BOLD signal frequency energy was
observed in the renal cortex. We hypothesize this corresponds to a decrease in O 2 utilization due to decreased renal H 2 O reabsorption.
15:30 4681. Functional Renal Imaging with BOLD: Validation of a Model for R2* in Kidney
Cortex and Medulla
Jeff Lei Zhang 1 , Henry Rusinek 1 , Hersh Chandarana 1 , Pippa Storey 1 , Eric E. Sigmund 1 ,
Pierre Hugues Vivier 1,2 , Qun Chen 1 , Hua Guo 1 , Vivian S. Lee 1
1 Department of Radiology, New York University, New York, NY, United States; 2 Rouen University Hospital,
Rouen, France
In this study we used a Monte Carlo simulation approach to explore the mechanism of BOLD R2* contrast in kidney. Kidney pO2
levels predicted based on R2* values by the simulation were in agreement with literature values for a healthy volunteer, and correlated
well with pO2 values measured by microprobe for diabetic rats of a previous study. The results indicate that the approach is a
promising tool for quantifying kidney oxygenation level based on BOLD data.
Tuesday 13:30-15:30 Computer 99
13:30 4682. Effect of Octreotide on Intra-Renal Oxygenation as Estimated by BOLD MRI in
Rats
Lu-Ping Li 1 , Joann Carbray 1 , Pottumarthi V. Prasad 1
1 Radiology, Northshore University Healthsystem, Evanston, IL, United States
Previous observations have shown lower intra-renal oxygenation as early as two days after induction of type I diabetes. In order to test
the hypothesis that this may be related to the direct effect of hyperglycemia, the infusion of glucose solution was used in healthy rats.
However comparable levels of blood glucose levels and R2* values in diabetic rats were observed only in animals pretreated with an
insulin inhibitor (octeotride). Because octeotride is associated with vasoconstriction, it is necessary to know the magnitude of any
direct effect of octeotride on renal oxygenation. That was the motivation for the present study.
14:00 4683. BOLD Changes After Revascularization in Renal Artery Stenosis Patients -
Preliminary Results
Iosif Alexandru Mendichovszky 1 , Constantina Chrysochou 2 , David L. Buckley 3 , Alan
Jackson 1 , Phil A. Kalra 2
1 Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, United Kingdom; 2 Renal
Department, Salford Royal Hospital, Salford, United Kingdom; 3 University of Leeds, Leeds, United Kingdom
Atheromatous renovascular disease is a commonly encountered yet challenging disease to manage. The aim of the current study was
to investigate renal parenchymal BOLD response to renal artery revascularization in patients with severe renal artery stenosis and
correlate imaging findings with changes in SK-GFR (as measured by radioisotope techniques). No significant differences were found
regarding baseline SK-GFR between kidneys that improved, remained stable, deteriorated or controls. R2* values were significantly
higher in kidneys whose renal function subsequently improved vs. those who stayed stable, deteriorated or controls. In addition, the
ratio of R2* to SK-GFR was significantly greater in improver kidneys.