ELECTRONIC POSTER - ismrm

Wednesday 13:30-15:30 Computer 100
13:30 4702. Whole-Body MRI, Including Diffusion-Weighted Imaging, for Staging Malignant
Lymphoma: Direct Comparison to CT
Thomas Kwee 1 , Malou Vermoolen 1 , Erik Akkerman 2 , Henriëtte Quarles van Ufford 1 ,
Frederik Beek 1 , Inge Ludwig 3 , Marc Bierings 4 , Rob Fijnheer 5 , Marie-José Kersten 6 ,
Joseph Zsiros 7 , Willem Mali 1 , Rutger-Jan Nievelstein 1
1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2 Department of
Radiology, Academic Medical Center, Amsterdam, Netherlands; 3 Department of Hematology, University
Medical Center Utrecht, Utrecht, Netherlands; 4 Department of Pediatric Hematology, University Medical
Center Utrecht, Utrecht, Netherlands; 5 Department of Hematology, Meander Medical Center, Amersfoort,
Netherlands; 6 Department of Hematology, Academic Medical Center, Amsterdam, Netherlands; 7 Department of
Pediatric Hematology, Academic Medical Center, Amsterdam, Netherlands
This study aimed to assess the equivalence of whole-body MRI, including diffusion-weighted imaging (DWI), to computed
tomography (CT) for the initial staging of malignant lymphoma. To that end, 66 consecutive patients with newly diagnosed malignant
lymphoma prospectively underwent whole-body MRI (T1-weighted and short inversion time inversion recovery [n=66], and DWI
[n=62]) at 1.5T and CT. Whole-body MRI (both with and without DWI) was equal to staging using CT in the majority of patients,
while whole-body MRI overstaging occurs more frequently than whole-body MRI understaging (relative to CT).
14:00 4703. Contrast Edited T 2 SSFSE: A Potential Alternative to Diffusion Weighted EPI for
MRI Screening
Ananth J. Madhuranthakam 1 , Aya Yassin 2,3 , Jean H. Brittain 4 , David C. Alsop 2,3 , Neil M.
Rofsky 2,3
1 MR Applied Science Lab, GE Healthcare, Boston, MA, United States; 2 Radiology, Beth Israel Deaconess
Medical Center, Boston, MA, United States; 3 Harvard Medical School, Boston, MA, United States; 4 MR
Applied Science Lab, GE Healthcare, Madison, WI, United States
MRI has gained increased attention for whole-body screening of tumor metastasis. The commonly used sequences are STIR and DW-
EPI. However, both are SNR limited and require multiple signal averages increasing the total scan time. In addition, DW-EPI images
are also subject to distortion in larger FOVs, and are typically limited to low resolution, axial plane imaging. The primary objective of
whole-body screening is to minimize the background tissue signal while simultaneously highlighting tumor signal in a rapid
acquisition. Such a technique is presented in this work using SSFSE readout while suppressing signal from fat, fluid and blood
vessels.
14:30 4704. Assessing the Advantages of Whole Body Diffusion Tensor Imaging for Screening of
Bone Metastases
Matthew David Blackledge 1 , David J. Collins 1 , Toni Wallace 1 , Dow-Mu Koh 1 , Martin O.
Leach 1
1 CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton,
Surrey, United Kingdom
We have demonstrated that the use of whole body DTI is feasible and practicable in the time required to obtain standard diffusion
weighted whole body measurements of bone metastases without significant loss in image quality. Furthermore it is possible to
measure useful biological parameters such as fractional anisotropy which may have direct clinical relevance in detecting spinal cord
compression.
15:00 4705. ADC Measurements in the Evaluation of Lymph Nodes in Patients with Non-
Hodgkin Lymphoma
Thomas Kwee 1 , Inge Ludwig 2 , Cuno Uiterwaal 3 , Henriëtte Quarles van Ufford 1 , Marc
Bierings 4 , Rob Fijnheer 5 , Taro Takahara 1 , Rutger-Jan Nievelstein 1
1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2 Department of
Hematology, University Medical Center Utrecht, Utrecht, Netherlands; 3 Julius Center for Health Sciences and
Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; 4 Department of Pediatric Hematology,
University Medical Center Utrecht, Utrecht, Netherlands; 5 Department of Hematology, Meander Medical
Center, Amersfoort, Netherlands
This study aimed to investigate whether apparent diffusion coefficient (ADC) measurements allow discriminating normal lymph
nodes from lymphomatous lymph nodes, and indolent lymphomas from aggressive lymphomas in patients with non-Hodgkin
lymphoma (NHL). To that end, 18 healthy volunteers and 22 patients with newly diagnosed NHL (indolent: n=9; aggressive: n=13)
prospectively underwent diffusion-weighted imaging at 1.5 T. Our results suggest that ADC measurements may be a highly specific
method for discriminating normal lymph nodes from lymphomatous lymph nodes in patients with NHL. However, ADC
measurements appear to be of no utility in differentiating indolent from aggressive lymphomas.