ELECTRONIC POSTER - ismrm

changes in leukoaraiosis include both an ischemic and a toxicity component, suggesting a central role of vascular endothelium in the
formation of leukoaraiosis.
14:00 4351. Relation Between Cerebral Small Vessel Disease and Vascular Reactivity - A 7 Tesla
Study
Mandy Conijn 1 , Hans Hoogduin, Jeroen Hendrikse, Mirjam Geerlings, Peter Luijten
1 Radiology, University Medical Center Utrecht, Utrecht, Netherlands
Lacunar infarcts and white matter lesions are thought to be caused by changes in the small vessels of the brain. It is possible that these
changes influence the vascular reactivity in the brain. This study assessed if the presence of lacunar infarcts or white matter lesions is
associated with a reduction of vascular reactivity, measured through the BOLD response at 7T. Both the whole brain signal change
and the percentage of activated voxels were significantly decreased in patients with lacunar infarcts, but both measures were not
related to white matter lesions.
14:30 4352. Characteristics of White Matter Hyperintensities in MR Images of Cerebral
Amyloid Angiopathy
Junya Konishi 1,2 , Julien Milles 2 , Jeroen van der Grond 2 , Mark A. van Buchem 2
1 Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan; 2 Department of
Radiology, Leiden University Medical Center, Leiden, Netherlands
MRI manifestations of cerebral amyloid angiopathy (CAA) are white matter hyperintensities (WMH) and cerebral micobleeds (CMB),
and the characteristics of CAA-related WMH have not been studied before. The purpose of this study was to study the volume and
distribution of CAA-related WMH using an automated method for probability maps and voxelwise statistical maps of WMH on MRI.
Our study demonstrated that CMB are associated with WMH, and increased numbers are associated with increased volumes of WMH.
Also we found evidence for differences in distribution of WMH associated with CAA-type CMB as compared to other types of CMB.
15:00 4353. Asymmetric Dilatation of Virchow-Robin Space in Unilateral Internal Carotid
Artery Stenosis
Tae-Sub Chung 1 , Ah Young Park 1 , Sang Huyn Suh 1
1 Diagnostic Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea,
Republic of
Problem: To test the hypothesis that chronic ischemia followed by white matter atrophy is associated with Virchow-Robin spaces
(VRSs) dilatation by determining the relationship between unilateral internal carotid artery (ICA) stenosis and asymmetric dilatation
of VRSs on the same side. Methods: We retrospectively reviewed axial T2-weighted and diffusion weighted MR images (GE Signa
Excita 3-T) of 46 patients with severe unilateral ICA stenosis (>70%), diagnosed by carotid contrast MRA and carotid digital
subtraction angiography (DSA) between Feb. 2007 and Sep. 2009. Hyperintense lesions in the pre- and post-central gyri and corona
radiata along CST pathway in the high convexity white matter on T2WI were included as VRSs. All lesions were graded into score 0
(None), score 1 (linear hyperintensity not extending to the corona radiata), score 2 (linear hyperintensity extending to the corona
radiata) and score 3 (round or oval hyperintensity larger than 2mm). We statistically analyzed the difference of VRSs score between
bilateral hemispheres, the correlation between VRSs socre and severity of ICA stenosis, the correlation between VRSs score and age,
and the difference of ipsilateral VRSs scores according to existence of infarction. Results: The VRSs on the ipsilateral and
contralateral sides showed statistical difference (p