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Thursday 13:30-15:30 Computer 90 13:30 4546. Breast BOLD Correlates to Optical Breast Imaging During Respiratory Stimulus Colin Morehouse Carpenter 1,2 , Rebecca Rakow-Penner 3 , Shudong Jiang 2 , Brian William Pogue 2 , Keith David Paulsen 2 , Gary H. Glover 3 1 Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States; 2 Thayer School of Engineering at Dartmouth, Hanover, NH, United States; 3 Radiology, Stanford University School of Medicine, Stanford, CA, United States BOLD response in the breast was measured concurrently with MR-guided diffuse optical tomography (MRg-DOT) in 11 healthy volunteers during inspired gas changes. This approach utilized optical imaging to quantitatively identify the independent effects of oxy- and deoxyhemoglobin. A key factor in this study was characterization of the background physiological noise variations in individual subjects, which was measured via optical imaging during air breathing. The results from this work indicate that BOLD and optically-determined deoxyhemoglobin signals correlate significantly in the breast during an oxygen/carbogen respiratory stimulus, as long as only subjects that exhibit a significant response are included. 14:00 4547. MR Breast Density Measurement: Comparison of Two Anatomic Landmarks for Breast Segmentation Jeon-Hor Chen 1,2 , Shih-Ting Chen 2 , Cheng-Ju Lin 2 , Daniel Chang 1 , Po-Pang Tsai 2 , Ke Nie 1 , Orhan Nalcioglu 1 , M-Y Lydia Su 1 1 Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States; 2 China Medical University Hospital, Taichung, Taiwan Although breast density measurement showed high correlation using both anatomic landmarks, there was still an average of 20% difference for FV measurement. A significant number of women had the problem of being cut off of their fibroglandular tissue when the pectoris major muscle was used as the landmark. From our study, it was concluded that in women with dense breast such as the subjects included in this study, both anatomic landmarks, especially the one anterior to the pectoris major muscle, will have the problem of cut-off of the fibroglandular tissue, resulting in the acquired fibroglandular tissue underestimated. 14:30 4548. Comparison of Breast Density Measured on Fat-Suppressed Versus Non-Fat- Suppressed MRI Daniel Han-en Chang 1 , Jeon-Hor Chen 1,2 , Shadfar Bahri 1 , Hon J. Yu 1 , Ke Nie 1 , Orhan Nalcioglu 1 , Min-Ying Lydia Su 1 1 Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2 Department of Radiology, China Medical University Hospital, Taichung, Taiwan Mammographic density is known to be strongly associated with the risk of breast cancer development, but using mammography to characterize breast density does not provide true volumetric information. MRI-based methods on the other hand provide promising alternatives, but may be affected by technical factors such as the choice of pulse sequences. We imaged breasts with two commonly used pulse sequences, fat-suppression and non-fat-suppression, and calculated their densities with an MRI-based method developed previously by our lab. We found that their densities are highly correlated and that fat-saturated images tend to have stronger relative tissue contrast. 15:00 4549. Correction of Skin Volume in the Breast Density Measured by MRI Ke Nie 1 , Daniel Chang 1 , Jeon-Hor Chen 1,2 , Tzh-Ching Shih 1,2 , Chieh-Chih Hsu 2 , Orhan Nalcioglu 1 , Min-Ying Lydia Su 1 1 Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, Irvine, CA, United States; 2 Department of Radiology, China Medical University, Taichung, Taiwan There is a great interest to correlate between the density measured on MRI and mammogram, so the established role for mammographic density may be extended to MRI-based density. One problem specific to volumetric MRI analysis is the inclusion of skin as the dense tissue. In contrast this effect could be ignored on projection mammogram. In this study, we investigated the correlation between the volume of the skin and the breast on 3D MRI. We further provided two correction models aiming to provide an estimation of the skin volume and its effect on MRI based density measurement.
Breast MR Hall B Monday 14:00-16:00 Computer 91 14:00 4550. Contrast-Enhanced 1.5-T MR Imaging of the Breast: Association Between Asymmetric Increase of Whole Breast Vascularity and Ipsilateral Cancer on a Series of 384 Studies Luca Alessandro Carbonaro 1 , Nicola Verardi, Henrida Kule, Giovanni Di Leo, Francesco Sardanelli 1 1 Unit of Radiology, Università degli Studi di Milano, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy We estimated the value of the breast vascular map asymmetry (BVMA) as a marker of ipsilateral tumors. Three-hundred-eighty-four patients underwent a dynamic study. We looked for BVMA. Pathologic examination or follow-up served as a reference standard. Pathology revealed 173 malignant lesions and 211 benign lesions. BVMA showed high diagnostic performance. Sensitivity was 76% for invasive cancers and 39% for in-situ cancers (P
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ELECTRONIC POSTER Cartilage Hall B
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14:00 3173. Sodium MRI: A Reproduci
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15:00 3182. Comparison of Short Ech
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15:00 3191. The Application of Magn
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to unity. Conversely, in trabecular
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determination of perfusion and perm
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unique ability of UTE MRI to direct
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throughout the maturation process,
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lipoatrophy with decreased of the l
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Tuesday 13:30-15:30 Computer 6 13:3
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15:00 3267. Dynamic Hyperpolarized
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Hall B Monday 14:00-16:00 Computer
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hyperpolarized for use as a metabol
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15:30 3295. 1 H Decoupled 13 C MRS
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use of short and high bandwidth adi
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Wednesday 13:30-15:30 Computer 10 1
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14:30 3325. Modeling of 3-Dimension
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Thursday 13:30-15:30 Computer 11 13
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14:00 3345. An Optimized T1nom Appr
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Increasing spatial resolution is ad
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14:30 3362. NMR Plasma Profiling of
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Spectroscopic Localization & Imagin
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total scan time and remove the spac
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Tuesday 13:30-15:30 Computer 18 13:
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15:00 3415. Modeling Neuronal Curre
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14:30 3425. A Randomized Global Sig
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15:00 3435. Investigating the Feasi
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BOLD activation within parenchymal
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15:00 3455. Understanding the Limit
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14:00 3465. Effect of EEG Electrode
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14:30 3486. Magnetization Transfer
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15:00 3506. DMN Is Affected Incongr
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the brain edge. Upon detrending thi
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healthy controls using empathy for
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activates superior colliculus and l
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Myocardial Function Human & Experim
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14:30 3562. Cardiac Torsion and Str
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14:30 3582. Early Diastolic Strain-
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Non-Cartesian k-space trajectories
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14:30 3601. Analysis of Cardio-Resp
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15:00 3611. An Optimal Physiologic
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depending on its linear or centric
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3Tesla using a 32 channel cardiac c
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States; 5 Chemistry & Chemical Engi
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similar set of fully sampled data.
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demonstrated 35% improvement in blo
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15:00 3679. Toward a Novel Implanta
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14:30 3697. Time-Resolved Spin-Labe
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and 13 patients, including peak and
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facilitate in the robust and reprod
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accurate quantification. The -goal
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and then auto-transplanted back to
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14:30 3755. The Use of Cellular MRI
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sampling patterns which are tailore
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with potential for improving diagno
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14:30 3795. Targeted Travelling Wav
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14:30 3806. A 8 Channel TX/RX Decou
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14:30 3827. A Mechanically Tuned 8-
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Receive Arrays Hall B Monday 14:00-
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15:00 3848. A Combined Solenoid-Sur
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the past and thus yields more reali
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14:30 3870. SAR Sensitivity to Phas
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heart between 20 and 40°C. As a re
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challenges for its simultaneous com
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experimental results showed the bes
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14:30 3922. Six Layers Stripline RF
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and a relaxed fixed point iteration
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15:00 3955. Improved PET Data Quant
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existing parallel imaging and parti
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14:30 4026. Classification of Non-G
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Arterial Spin Labeling: Methods Hal
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using both methods but the differen
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estimates. Differences in delays an
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angioplasty balloon in the aorta. T
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14:30 4134. Optimal Ultrasonic Focu
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14:30 4144. TMAP @ IFE - A Framewor
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Cell Tracking II Hall B Monday 14:0
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14:30 4192. Quantification of Cell
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are not sensitive to early abnormal
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14:30 4240. DCE-MRI and DW-MRI in C
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15:00 4249. Are Behavioural Symptom
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were observed from the preCG and IC
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14:00 4267. Absolute Quantification
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Vergata"; 6 Cognition and Cognitive
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secular-T2 peaks revealed significa
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Page 245 and 246: 14:00 4355. In Vivo Quantitative Im
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present initial results in terms of
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14:30 4794. Bax-Deficiency Reduces
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of Cardiology, Munich University Ho
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appropriately describes the uptake
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Tuesday 13:30-15:30 Computer 108 13
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tumour. A significant reduction in
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14:30 4838. Detection and Improveme
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15:00 4846. The Assessment of Early
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Our results indicate that the propo
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egularizing terms that may affect t
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times due to the need of additional
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proposed homotopic L0 minimization
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1 Imaging Division, UMC utrecht, Ut
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Wednesday 13:30-15:30 Computer 116
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frequency k-space data are processe
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cylinders trajectory and have imple
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still requires scan durations not a
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14:00 5016. High Spatial and Tempor
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perform the AC of the SPECT data. T
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15:30 5058. Reducing Ghosting in EP
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Wednesday 13:30-15:30 Computer 124
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egularization parameter is adapted
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14:00 5108. Correction Algorithm fo
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IDEAL knee MRI data is proposed. Va
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14:30 5129. Design of Iron Sensitiv
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