ELECTRONIC POSTER - ismrm

dimensions of hyperpolarized 13C CSI acquisitions. Phantom experiments showed an improved point-spread function and a rat study
showed the feasibility of using the method for in vivo data acquisition.
15:30 3263. The Effects of Contrast Agents on Hyperpolarised [1- 13 C]-Pyruvic Acid
Lanette Friesen Waldner 1,2 , Timothy Scholl 3 , Albert Chen 4 , Brian Rutt, 1,5 , Charles
McKenzie, 12
1 Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada; 2 Medical Biophysics, The
University of Western Ontario, London, ON, Canada; 3 Physics and Astronomy, The University of Western
Ontario, London, ON, Canada; 4 GE Healthcare, Toronto, ON, Canada; 5 Diagnostic Radiology and Richard M
Lucas Center for Imaging, Stanford University, Stanford, CA, United States
The addition of small quantities of gadolinium based contrast agents (GBCA) to 13 C-enriched samples containing trityl radical
significantly increases the hyperpolarisation that can be obtained via dynamic nuclear polarisation. This study examined the effects of
several contrast agents on T 1 in solution and on relative hyperpolarisation in the solid state in [1- 13 C]-labeled pyruvic acid. T 1
decreased with increasing contrast agent concentration with all contrast agents except Teslascan. Dotarem and ProHance showed a
slight decrease in T 1 . MultiHance showed the largest increase in hyperpolarisation and the largest decrease in T 1 . The choice of
contrast agent may depend on the application.
Tuesday 13:30-15:30 Computer 7
13:30 3264. Simulation Tool for Modeling of Hyperpolarized 13 C Metabolic Imaging:
Application to Optimizing 13 C-Fructose Acquisitions
Peter J. Shin 1,2 , Simon Hu 2 , Peder E. Z. Larson 2 , Kayvan R. Keshari 2 , John
Kurhanewicz 1,2 , Daniel B. Vigneron 1,2
1 Joint Graduate Group in Bioengineering, University of California at San Francisco & Berkeley, San Francisco,
CA, United States; 2 Department of Radiology and Biomedical Imaging, University of California at San
Francisco, San Francisco, CA, United States
13 C-fructose has been recently proposed as a novel hyperpolarized 13 C probe. The short T 1 of 13 C-fructose could impose additional
challenges in designing data acquisition strategies. Here, we have optimized an acquisition scheme using a specialized simulation tool
and showed that a T 1 compensated RF excitation scheme together with compressed sensing can yield minimized spatial blurring with
high SNR enough for in vivo 13 C-fructose metabolic imaging.
14:00 3265. Bloch Equation Simulations for BSSFP, Spin Echo, and SPGR Sequences When
Using Hyperpolarized Carbon-13
Eric Peterson 1 , Kang Wang 2 , Sean Fain 2,3
1 Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States; 2 Medical Physics,
University of Wisconsin - Madison, Madison, WI, United States; 3 Radiology, University of Wisconsin -
Madison, Madison, WI, United States
Current hyperpolarized carbon protocols call for all of the scans to be performed in series, including the proton localizer and carbon
metabolic image. The localizer image is typically acquired at a higher resolution than the carbon image, and eventually serves as an
anatomical reference for the later carbon acquisition. By performing a simultaneous proton and carbon acquisition, several potential
applications are possible such as continuous localization, motion tracking and compensation, or targeted excitation.
14:30 3266. View-Order Consideration for Hyperpolarized C-13 Imaging with Radial
Acquisition and Projection Reconstruction
Kang Wang 1 , Eric Peterson 2 , Jeremy Gordon 1 , Krishna Kurpad 3 , Ian Rowland 3 , Matthew
Erickson 3 , Sean Fain 1,3
1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2 Biomedical Engineering,
University of Wisconsin-Madison, Madison, WI, United States; 3 Radiology, University of Wisconsin-Madison,
Madison, WI, United States
Since hyperpolarized (HP) C-13 compounds exhibit non-equilibrium T1 decay and rapidly evolving spectral dynamics, fast imaging
techniques such as radial acquisition have favorable characteristics which allow them to be combined with spectral imaging methods
and thus follow the spectral dynamics. Due to the non-equilibrium of the magnetization, the acquired k-space will be modulated and
the projection order needs to be designed to minimize spatial artifacts. In this work, we investigated, qualitatively and quantitatively,
three different view-order schemes for 2D radial acquisitions. A superior scheme for minimizing artifacts in HP C-13 radial imaging
was found.