ELECTRONIC POSTER - ismrm
ELECTRONIC POSTER - ismrm
ELECTRONIC POSTER - ismrm
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Multiple Sclerosis I<br />
Hall B Monday 14:00-16:00 Computer 76<br />
14:00 4310. Magnetization Transfer (MT) and Endogenous Chemical Exchange Saturation<br />
Transfer (CEST) Effects in Patients with Clinically Isolated Syndrome<br />
Ali Al-Radaideh 1 , Olivier Mougin 1 , Su-Yin Lim 2 , Christopher Tench 2 , Cris<br />
Constantinescu 2 , Penny Gowland 1<br />
1 Sir Peter Mansfield MR Centre, The University Of Nottingham, Nottingham, Nottinghamshire, United<br />
Kingdom; 2 Clinical Neurology, The University Of Nottingham, Nottingham, Nottinghamshire, United Kingdom<br />
Magnetization transfer (MT) is an important MRI measure in MS and the MT effect can be assessed qualitatively using magnetization<br />
transfer ratio (MTR) maps.A distinctive peak is observed in the z -spectrum of the human brain, at -1.05k Hz offset from the water<br />
frequency at 7T. This is caused by endogenous chemical exchange saturation transfer (CEST) between amide (chemical group<br />
attached to the peptide bond) and water protons. Here we obtain MTR images for negative (MTR- sensitive to MT + CEST effects)<br />
and positive (MTR+ sensitive to just MT effects) frequency offsets of the saturation and compare the distributions of these parameters<br />
in NAWM of healthy controls and patients with Clinically Isolated Syndrome (CIS: a condition that is likely to lead to MS).<br />
14:30 4311. Application of CEST Imaging to Study Amide Proton Transfer (APT) in Healthy<br />
Controls and Multiple Sclerosis Pathology at 7 Tesla<br />
Adrienne N. Dula 1,2 , Richard D. Dortch 1,2 , Bennett A. Landman 2,3 , Sid Pawate 4 , Patrick J.<br />
Lavin 4 , Edward B. Welch, 1,5 , John C. Gore 1,2 , Seth A. Smith 1,2<br />
1 Vanderbilt Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2 Radiology and<br />
Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, United States; 3 Electrical Engineering &<br />
Computer Science, Vanderbilt University, Nashville, TN, United States; 4 Neurology, Vanderbilt Medical<br />
Center, Nashville, TN, United States; 5 3MR Clinical Science, Philips Healthcare, Cleveland, OH, United States<br />
Increased contrast from chemical exchange saturation transfer (CEST) effects in human brain at 7T has been used to study amide<br />
proton transfer (APT) and applied in multiple sclerosis (MS). APT imaging is sensitive to the mobile protons associated with proteins<br />
and peptides. The increased signal, T1, and spectral dispersion at 7T ameriorate this molecular MRI method. APT asymmetry analysis<br />
at 7T was used to examine unique white matter, gray matter contrast in healthy controls as well as an MS patient. Herein, we utilize<br />
the Water Spectrum Shift Reference (WASSR) method to correct for B0 inhomogeneities and center the CEST spectra.<br />
15:00 4312. Multimodal High Resolution Magnetization Transfer and T1mapping in NAWM of<br />
Patients with Clinically Isolated Syndrome<br />
Ali Al-Radaideh 1 , Olivier Mougin 1 , Su-Yin Lim 2 , Christopher Tench 2 , Cris<br />
Constantinescu 2 , Penny Gowland 1<br />
1 Sir Peter Mansfield MR Centre, The University of Nottingham, Nottingham, Nottinghamshire, United<br />
Kingdom; 2 Clinical Neurology, The University of Nottingham, Nottingham, Nottinghamshire, United Kingdom<br />
Multiple Sclerosis (MS) is known to reduce magnetization transfer ratio (MTR)and increase the longitudinal relaxation time (T1) in<br />
the white matter (WM). Here, we measure the distribution of MTR and T1 values in normal appearing white matter (NAWM) at 7T<br />
and high spatial resolution, comparing CIS patients with healthy controls.<br />
15:30 4313. Magnetization Transfer Weighted Double Inversion Recovery for an Improved<br />
Visualization of Neocortical and Juxtacortical Signal Abnormalities<br />
Christian Langkammer 1 , Christian Enzinger 1 , Siegrid Fuchs 1 , Franz Fazekas 1 , Stefan<br />
Ropele 1<br />
1 Department of Neurology, Medical University of Graz, Graz, Austria<br />
Signal abnormalities in multiple sclerosis such as neocortical and juxtacortical lesions can be visualized best using a double inversion<br />
recovery (DIR) sequence. DIR sequences are based on T1 filtering and aim on suppressing signal from white matter and cerebrospinal<br />
fluid. We here investigated, whether the application of additional MT saturation pulses can further improve the contrast between<br />
cortex, white matter and embedded lesions. The new sequence was evaluated in the brain of healthy volunteers and multiple sclerosis<br />
patients.<br />
Tuesday 13:30-15:30 Computer 76<br />
13:30 4314. Elimination of T 1 Weighting in FLAIR by Optimized Double IR – Could This Be the<br />
Only T 2 -Weighted Sequence Needed?<br />
Ananth J. Madhuranthakam 1 , Subhendra N. Sarkar 2,3 , Reed F. Busse 4 , David C. Alsop 2,3<br />
1 MR Applied Science Lab, GE Healthcare, Boston, MA, United States; 2 Radiology, Beth Israel Deaconess<br />
Medical Center, Boston, MA, United States; 3 Harvard Medical School, Boston, MA, United States; 4 MR<br />
Applied Science Lab, GE Healthcare, Madison, WI, United States<br />
FLAIR is widely used for its improved conspicuity of long T 2 lesions. However, concerns remain that the IR imparts T 1 weighting<br />
that can decrease detectability of some lesions. Frequently, both T 2 and FLAIR are used in clinical protocols to guard against these<br />
concerns. Recently, double IR (DIR) has been proposed to highlight some brain lesions by nulling both WM and CSF but produces