ELECTRONIC POSTER - ismrm

Thursday 13:30-15:30 Computer 90
13:30 4546. Breast BOLD Correlates to Optical Breast Imaging During Respiratory Stimulus
Colin Morehouse Carpenter 1,2 , Rebecca Rakow-Penner 3 , Shudong Jiang 2 , Brian William
Pogue 2 , Keith David Paulsen 2 , Gary H. Glover 3
1 Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States; 2 Thayer School of
Engineering at Dartmouth, Hanover, NH, United States; 3 Radiology, Stanford University School of Medicine,
Stanford, CA, United States
BOLD response in the breast was measured concurrently with MR-guided diffuse optical tomography (MRg-DOT) in 11 healthy
volunteers during inspired gas changes. This approach utilized optical imaging to quantitatively identify the independent effects of
oxy- and deoxyhemoglobin. A key factor in this study was characterization of the background physiological noise variations in
individual subjects, which was measured via optical imaging during air breathing. The results from this work indicate that BOLD and
optically-determined deoxyhemoglobin signals correlate significantly in the breast during an oxygen/carbogen respiratory stimulus, as
long as only subjects that exhibit a significant response are included.
14:00 4547. MR Breast Density Measurement: Comparison of Two Anatomic Landmarks for
Breast Segmentation
Jeon-Hor Chen 1,2 , Shih-Ting Chen 2 , Cheng-Ju Lin 2 , Daniel Chang 1 , Po-Pang Tsai 2 , Ke
Nie 1 , Orhan Nalcioglu 1 , M-Y Lydia Su 1
1 Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States; 2 China Medical University
Hospital, Taichung, Taiwan
Although breast density measurement showed high correlation using both anatomic landmarks, there was still an average of 20%
difference for FV measurement. A significant number of women had the problem of being cut off of their fibroglandular tissue when
the pectoris major muscle was used as the landmark. From our study, it was concluded that in women with dense breast such as the
subjects included in this study, both anatomic landmarks, especially the one anterior to the pectoris major muscle, will have the
problem of cut-off of the fibroglandular tissue, resulting in the acquired fibroglandular tissue underestimated.
14:30 4548. Comparison of Breast Density Measured on Fat-Suppressed Versus Non-Fat-
Suppressed MRI
Daniel Han-en Chang 1 , Jeon-Hor Chen 1,2 , Shadfar Bahri 1 , Hon J. Yu 1 , Ke Nie 1 , Orhan
Nalcioglu 1 , Min-Ying Lydia Su 1
1 Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States;
2 Department of Radiology, China Medical University Hospital, Taichung, Taiwan
Mammographic density is known to be strongly associated with the risk of breast cancer development, but using mammography to
characterize breast density does not provide true volumetric information. MRI-based methods on the other hand provide promising
alternatives, but may be affected by technical factors such as the choice of pulse sequences. We imaged breasts with two commonly
used pulse sequences, fat-suppression and non-fat-suppression, and calculated their densities with an MRI-based method developed
previously by our lab. We found that their densities are highly correlated and that fat-saturated images tend to have stronger relative
tissue contrast.
15:00 4549. Correction of Skin Volume in the Breast Density Measured by MRI
Ke Nie 1 , Daniel Chang 1 , Jeon-Hor Chen 1,2 , Tzh-Ching Shih 1,2 , Chieh-Chih Hsu 2 , Orhan
Nalcioglu 1 , Min-Ying Lydia Su 1
1 Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, Irvine, CA, United States;
2 Department of Radiology, China Medical University, Taichung, Taiwan
There is a great interest to correlate between the density measured on MRI and mammogram, so the established role for
mammographic density may be extended to MRI-based density. One problem specific to volumetric MRI analysis is the inclusion of
skin as the dense tissue. In contrast this effect could be ignored on projection mammogram. In this study, we investigated the
correlation between the volume of the skin and the breast on 3D MRI. We further provided two correction models aiming to provide
an estimation of the skin volume and its effect on MRI based density measurement.