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Scotland, United Kingdom; 5 Bruker BioSpin GmbH, Ettlingen, Germany; 6 Centre for Advanced Medical Imaging, St. James’s Hospital, Dublin, Ireland The aim of this study was to accurately quantify subtle changes in Tissue Sodium Concentration (TSC) during the acute phase in a rodent stroke model. A double-tuned 23 Na/ 1 H dual resonator system was developed and a 2D radial sequence optimized for qNa- MRM (voxel sizes of 1.2µl, TA = 10min). A quantification accuracy of
15:30 4505. Manganese-Enhanced MRI Detection of Neural Compensatory Changes After Neonatal Monocular Enucleation Iris Y. Zhou 1,2 , April M. Chow 1,2 , Shu Juan Fan 1,2 , Ed X. Wu 1,2 1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China In this study, in vivo MEMRI was introduced to investigate cellular alteration and manganese-induced signal intensity changes after neonatal monocular enucleation. With MEMRI, impaired superior colliculi with high spatial resolution revealing the laminar structure and enhancement of monocular area of primary visual cortex can be observed after neonatal monocular enucleation noninvasively. Such MEMRI approach may be useful in investigation of neural plasticity and the adaptive and compensatory modifications within the brain following neonatal monocular enucleation. Tuesday 13:30-15:30 Computer 88 13:30 4506. Manganese-Enhanced MRI of Perilesion Cortex in Subchronic Focal Brain Ischemia Kevin C. Chan 1,2 , Ed X. Wu 1,2 1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China In this study, MEMRI was employed to investigate into the late changes in Mn2+ enhancement in subchronic focal brain ischemia, with emphases on the temporal evolutions in different subregions of the perilesion cortex. The results of this study may provide a new tool for in vivo longitudinal monitoring of the of salvageable tissues and hence represent potential new therapeutic targets for improving the functional consequences after stroke. 14:00 4507. Bimodal FMRI for Exploring Brain Activity: A Striatal CBV Response Accompanied by Enhanced Nigrostriatal Activity Detected by MEMRI Chiao-Chi V. Chen 1 , Yi-Hua Hsu 2 , Chen Chang 2 1 Functional and Micro-Magnetic Resonance Imaging Center,, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2 Functional and Micro-Magnetic Resonance Imaging Center, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Brain activation can be evaluated by a bimodal fMRI protocol that utilizes hemodynamics based fMRI and manganese-enhanced MRI (MEMRI) in combination. The present study demonstrates a striatal CBV response accompanied by enhanced nigrostriatal activity detected by MEMRI following peripheral electrical stimulation. 14:30 4508. Regional Difference in Mn Uptake and Retention in Mouse Brain Abu-Bakar-Md-Ali Asad 1 , Kai-Hsiang Chuang 1 1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore We compared the difference in Mn uptake and retention rates at various brain regions after systemic administration of MnCl2. By estimating Mn concentration with the change in T1 relaxation rate (ΔR1), it was observed that different brain regions have considerable difference in the time-to-peak and bioelimination rate of Mn. The ΔR1-time course was fitted to a gamma variate model which showed reasonable fit and provides estimation of time-to-peak, peak value and half-life. The olfactory bulb reached the peak earliest and highest, while regions like thalamus reached peak at day 2. Olfactory bulb had fastest clearance with a half-life of 6.6 days, and cerebellum had longer half-life of 11.5 days. This method can allow better estimate of the uptake and retention and can be used to maximize tissue contrasts or applied to studying of transporter mechanism in animal models. 15:00 4509. Detection of Brain Activity During Chronic Pain Using Activity-Induced Manganese-Enhanced MRI in the Ra Yuko Kawai 1 , Masahiro Umeda 1 , Yasuharu Watanabe 1 , Toshihiro Higuchi 2 , Shoji Naruse 3 , Chuzo Tanaka 2 1 Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan; 2 Neurosurgery, Meiji University of Integrative Medicine, Kyoto, Japan; 3 Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan IntroductionzNerve injury occasionally induces neuropathic pain, which is a type of chronic pain. The cardinal symptom of neuropathic pain is spontaneous or touch-evoked pain. The purpose of this study is to detect brain activation during foot stimulation by using Activity-induced manganese-enhanced (AIM) MRI in a segmental spinal nerve ligation (SNL) model. Methods The right L5–L6 spinal nerves were ligated with 5–0 silk sutures. AIM MRI were acquired using a 4.7-T MRI system. ResultsPain-induced brain activation was successfully visualized using AIM MRI. It suggested that the AIM MRI is useful for the depiction of the conducting pathway of pain.
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ELECTRONIC POSTER Cartilage Hall B
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14:00 3173. Sodium MRI: A Reproduci
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15:00 3182. Comparison of Short Ech
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15:00 3191. The Application of Magn
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to unity. Conversely, in trabecular
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determination of perfusion and perm
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unique ability of UTE MRI to direct
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throughout the maturation process,
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lipoatrophy with decreased of the l
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Tuesday 13:30-15:30 Computer 6 13:3
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14:30 3258. 3D-FSE-Cube of the Foot
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15:00 3267. Dynamic Hyperpolarized
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Hall B Monday 14:00-16:00 Computer
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hyperpolarized for use as a metabol
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15:30 3295. 1 H Decoupled 13 C MRS
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use of short and high bandwidth adi
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Wednesday 13:30-15:30 Computer 10 1
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14:30 3325. Modeling of 3-Dimension
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Thursday 13:30-15:30 Computer 11 13
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14:00 3345. An Optimized T1nom Appr
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Increasing spatial resolution is ad
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14:30 3362. NMR Plasma Profiling of
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Spectroscopic Localization & Imagin
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total scan time and remove the spac
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15:00 3394. Phase-Based Contrast Ag
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Tuesday 13:30-15:30 Computer 18 13:
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15:00 3415. Modeling Neuronal Curre
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14:30 3425. A Randomized Global Sig
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15:00 3435. Investigating the Feasi
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BOLD activation within parenchymal
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15:00 3455. Understanding the Limit
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14:00 3465. Effect of EEG Electrode
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14:30 3486. Magnetization Transfer
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15:00 3506. DMN Is Affected Incongr
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the brain edge. Upon detrending thi
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healthy controls using empathy for
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14:30 3534. Single Word Reading in
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activates superior colliculus and l
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Myocardial Function Human & Experim
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14:30 3562. Cardiac Torsion and Str
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14:30 3582. Early Diastolic Strain-
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Non-Cartesian k-space trajectories
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14:30 3601. Analysis of Cardio-Resp
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15:00 3611. An Optimal Physiologic
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depending on its linear or centric
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3Tesla using a 32 channel cardiac c
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States; 5 Chemistry & Chemical Engi
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similar set of fully sampled data.
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demonstrated 35% improvement in blo
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15:00 3679. Toward a Novel Implanta
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14:30 3697. Time-Resolved Spin-Labe
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and 13 patients, including peak and
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facilitate in the robust and reprod
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accurate quantification. The -goal
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and then auto-transplanted back to
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14:30 3755. The Use of Cellular MRI
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sampling patterns which are tailore
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with potential for improving diagno
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14:30 3795. Targeted Travelling Wav
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14:30 3806. A 8 Channel TX/RX Decou
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Receive Arrays Hall B Monday 14:00-
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15:00 3848. A Combined Solenoid-Sur
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the past and thus yields more reali
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14:30 3870. SAR Sensitivity to Phas
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heart between 20 and 40°C. As a re
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challenges for its simultaneous com
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experimental results showed the bes
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14:30 3922. Six Layers Stripline RF
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14:30 3933. Eigenmode Analysis of E
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and a relaxed fixed point iteration
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15:00 3955. Improved PET Data Quant
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15:00 3966. Diffusion Properties of
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14:00 3985. Development of a WM Atl
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existing parallel imaging and parti
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15:00 4016. Application of Rotation
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14:30 4026. Classification of Non-G
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15:00 4036. Sensitivity of Motion E
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14:00 4046. Effects of Hypercapnia
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Arterial Spin Labeling: Methods Hal
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14:30 4066. Accounting for Dispersi
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using both methods but the differen
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estimates. Differences in delays an
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angioplasty balloon in the aorta. T
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14:30 4134. Optimal Ultrasonic Focu
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14:30 4144. TMAP @ IFE - A Framewor
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14:30 4164. Transmit Power Optimiza
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15:00 4173. Magnetic Resonance Micr
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Cell Tracking II Hall B Monday 14:0
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14:30 4192. Quantification of Cell
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15:30 4201. Characterisation of a L
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are not sensitive to early abnormal
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14:30 4240. DCE-MRI and DW-MRI in C
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15:00 4249. Are Behavioural Symptom
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were observed from the preCG and IC
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Page 245 and 246: 14:00 4355. In Vivo Quantitative Im
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15:00 4740. Histopathological Compo
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prevention. In this study we have e
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15:00 4758. Quantitative Analysis o
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15:00 4767. DCE-MRI for the Detecti
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Tuesday 13:30-15:30 Computer 105 13
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present initial results in terms of
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14:30 4794. Bax-Deficiency Reduces
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of Cardiology, Munich University Ho
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appropriately describes the uptake
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tumour. A significant reduction in
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14:30 4838. Detection and Improveme
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15:00 4846. The Assessment of Early
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Our results indicate that the propo
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egularizing terms that may affect t
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times due to the need of additional
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proposed homotopic L0 minimization
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15:00 4910. Auto-Calibrated Paralle
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1 Imaging Division, UMC utrecht, Ut
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Wednesday 13:30-15:30 Computer 116
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frequency k-space data are processe
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cylinders trajectory and have imple
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still requires scan durations not a
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15:00 5006. A T 2 * Selective Highe
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14:00 5016. High Spatial and Tempor
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14:00 5036. Real-Time Motion Correc
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perform the AC of the SPECT data. T
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15:30 5058. Reducing Ghosting in EP
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Wednesday 13:30-15:30 Computer 124
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egularization parameter is adapted
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14:00 5108. Correction Algorithm fo
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IDEAL knee MRI data is proposed. Va
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14:30 5129. Design of Iron Sensitiv
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